{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:45:15Z","timestamp":1750434315849,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperproteinorrachia (raised cerebrospinal fluid total protein [CSF\u2010TP]) without pleocytosis (HP) (also known as albuminocytologic dissociation) is identified in dogs with different neurologic diseases. However, the association between survival and increased CSF\u2010TP is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>(a) Identify conditions commonly associated with HP in dogs and (b) investigate whether higher CSF\u2010TP concentrations or other relevant factors are associated with 1\u2010year survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study that identified dogs with HP (Cisternal CSF\u2010TP &gt;0.30\u00a0g\/L, Lumbar CSF\u2010TP &gt;0.45\u00a0g\/L with total nucleated cell concentrations [TNCCs] and RBC counts within RIs) from 2008 to 2019: recording signalment, weight, vital parameters, inflammation, neuroanatomic localization, CSF\u2010TP, sampling site, final diagnosis, etiologic classification, and 1\u2010year survival. Corrected CSF\u2010TP was calculated as CSF\u2010TP minus 0.3 (cisternal) or 0.45 (lumbar or unknown). Descriptive statistics were produced, CSF\u2010TP differences between groups (eg, neuroanatomic localizations) were evaluated using the Mann\u2010Whitney<jats:italic>U<\/jats:italic>test or Kruskal\u2010Wallis test (post\u2010hoc testing). The Cox proportional hazards model was used for survival data. Statistical significance was set at a<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 39 dogs had HP, associated with 17 conditions, including neoplasia (n\u00a0=\u00a06), meningoencephalitis of unknown origin (n\u00a0=\u00a04) (MUO), and intervertebral disc disease (n\u00a0=\u00a04) (IVDD) as the most common conditions. There was no significant difference between the CSF\u2010TP\/corrected CSF\u2010TP between 1\u2010year survivors and non\u2010survivors, nor was there a difference between different neuroanatomic localizations or etiologic classifications (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Neoplasia, after adjustment for age, was the only variable associated with a worse survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01 HR: 2.08 (95% CI: 1.65\u201039.2). CSF\u2010TP was not associated with age (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HP in dogs is associated with a wide range of conditions; the most common conditions are neoplasia, MUO, and IVDD. Higher CSF\u2010TP levels do not correlate with a worse 1\u2010year survival; however, they do correlate with neoplastic lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.12984","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T04:21:35Z","timestamp":1629951695000},"page":"376-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective evaluation of hyperproteinorrachia without pleocytosis (albuminocytologic dissociation) and survival in dogs"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-919X","authenticated-orcid":false,"given":"Alexandra C. E.","family":"Draper","sequence":"first","affiliation":[{"name":"Queen\u2019s Veterinary Hospital University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J. C.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Millennium Veterinary Practice Braintree UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Queen\u2019s Veterinary Hospital University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Archer","sequence":"additional","affiliation":[{"name":"Queen\u2019s Veterinary Hospital University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Alves","sequence":"additional","affiliation":[{"name":"Queen\u2019s Veterinary Hospital University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"481","volume-title":"BSAVA Manual of Canine and Feline Clinical Pathology","author":"Villier E","year":"2016"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1016\/B978-0-12-370491-7.00026-X"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1161\/01.STR.21.2.348"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1136\/bmjopen-2018-025348"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.4081\/ni.2017.7032"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1016\/S0034-5288(18)31936-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.22233\/9781910443125.2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.3389\/fonc.2019.01151"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1136\/vr.101431"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1111\/j.1939-1676.2008.0141.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.3389\/fvets.2019.00286"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1111\/j.1748-5827.2001.tb02458.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1111\/j.1939-1676.2008.0170.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1111\/jvim.15700"},{"issue":"7","key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.2460\/javma.1997.211.07.866","article-title":"Effects of iatrogenic blood contamination on results of cerebrospinal fluid analysis in clinically normal dogs and dogs with neurologic disease","volume":"211","author":"Hurtt AE","year":"1997","journal-title":"J Am Vet Med Assoc"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.12984","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.12984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T07:21:14Z","timestamp":1725693674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.12984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/vcp.12984"],"URL":"https:\/\/doi.org\/10.1111\/vcp.12984","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"type":"print","value":"0275-6382"},{"type":"electronic","value":"1939-165X"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"assertion":[{"value":"2020-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}