{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:48Z","timestamp":1787016048146,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 6.2\u2010year\u2010old 28\u2010kg (61.7\u00a0lb) intact female Golden Retriever was referred due to persistent and multiple cytopenias noted on a routine CBC prior to a mature ovariohysterectomy procedure. The patient's physical examination was unremarkable, and staging of the thorax and abdomen identified no abnormalities. At the referral hospital, moderate hypercalcemia, borderline anemia, and neutropenia were noted. Assessment of bone marrow samples by cytology, histology, immunohistochemistry, and flow cytometry indicated a T\u2010cell neoplasm. The patient was treated with a multi\u2010agent chemotherapy protocol for 6\u00a0months, which induced remission. Nine months after diagnosis, she relapsed with recurrence of hypercalcemia, cytopenias, and clinical illness. Single\u2010agent anthracycline (mitoxantrone) in combination with prednisone therapy was initiated for 3\u00a0months. Two months after completion, the patient relapsed again, and palliative therapy with prednisone was elected. The patient was euthanized 16\u00a0months after diagnosis due to progressive disease. Post\u2010mortem histopathologic evaluation showed extensive replacement of bone marrow by neoplastic cells, and infiltrates in multiple organs. The neoplasm was diagnosed as lymphoma rather than leukemia due to the lack of abnormal circulating cells throughout the course of disease. The neoplasm was detected only in marrow at the time of initial diagnosis, and the marrow was the most extensively effaced organ at the time of death. Therefore, leukemia or stage V lymphoma was considered unlikely. In patients with a cytopenia and lack of neoplastic leukocytosis or solid tissue masses, primary bone marrow lymphoma should be considered among the differential diagnoses.<\/jats:p>","DOI":"10.1111\/vcp.13009","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T22:51:13Z","timestamp":1616539873000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary bone marrow T\u2010cell lymphoma in a Golden Retriever"],"prefix":"10.1111","volume":"50","author":[{"given":"Christopher J.","family":"Pinard","sequence":"first","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"},{"name":"Animal Cancer Centre Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latasha","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Tatiersky","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Brooks","sequence":"additional","affiliation":[{"name":"Animal Cancer Centre Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"},{"name":"Animal Cancer Centre Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel E","family":"Hocker","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Ontario Veterinary College University of Guelph Guelph ON Canada"},{"name":"Animal Cancer Centre Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-2931","authenticated-orcid":false,"given":"Dorothee","family":"Bienzle","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Ontario Veterinary College University of Guelph Guelph ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12843"},{"key":"e_1_2_6_3_1","first-page":"688","volume-title":"Withrow and MacEwen\u2019s Small Animal Clinical Oncology","author":"Vail DM","year":"2020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci3020011"},{"key":"e_1_2_6_5_1","first-page":"102","volume-title":"Jubb, Kennedy & Palmer\u2019s Pathology of Domestic Animals","author":"Valli VEO","year":"2015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.131.3.1505457"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"120","article-title":"Dry tap: a diagnostic alert for underlying bone marrow pathology","volume":"27","author":"Ahmad SQ","year":"2015","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379428"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00099.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812451625"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2017.07.008"},{"key":"e_1_2_6_12_1","first-page":"351","volume-title":"Jubb, Kennedy & Palmer\u2019s Pathology of Domestic Animals","author":"Cullen JM","year":"2015"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31823ea106"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2178"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1129-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001625746"}],"updated-by":[{"DOI":"10.1111\/vcp.13035","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000}}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.13009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T20:21:03Z","timestamp":1693599663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.13009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/vcp.13009"],"URL":"https:\/\/doi.org\/10.1111\/vcp.13009","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"2020-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}