{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:22:30Z","timestamp":1792178550021,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Feline obstructive disease of the lower urinary tract (FLUTD) is a common pathologic condition of cats. It can be related to sterile inflammation, which leads to acute impairment of renal function and the accumulation of electrolytes and acid\u2010base imbalance. Acute\u2010phase proteins (APPs) are biomarkers of tissue damage from inflammation that assist in monitoring treatment and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Monitoring the inflammatory processes of obstructive feline lower urinary tract disease through the determination of plasma fibrinogen concentrations and serum concentrations of the acute\u2010phase proteins, serum amyloid A (SAA), alpha\u20101\u2010acid glycoprotein (AGP), and albumin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Twenty\u2010five male cats were included in this study. They were divided into two experimental groups: a control group (CG) and an obstruction group (OG). There were 8 healthy cats in the CG group and 17 cats with obstructive FLUTD in the OG group. APP measurements were conducted using ELISA kits. Samples were collected for APP analyses, serum biochemical assays, urinalyses, and urine protein: creatinine ratio calculations at diagnosis, before urethral clearance (H0), and 12 (H12), 24 (H24), and 48 (H48) hours after urethral clearance from cats in the OG group. Samples were collected once from cats in the CG group cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At H0, we found positive correlations of SAA, AGP, and fibrinogen with urea and creatinine, and negative correlations of albumin with hematuria, SAA, and potassium. At H48, we found positive correlations between SAA and AGP, AGP and urea, fibrinogen and urea, fibrinogen and creatinine, fibrinogen and AGP, and fibrinogen and SAA. In addition, a negative correlation of albumin with urea and creatinine was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum amyloid A, AGP, fibrinogen, and albumin could be used as biomarkers of inflammatory processes in cats with obstructive FLUTD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.13047","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T04:08:41Z","timestamp":1645502921000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Acute\u2010phase proteins in cats with obstructive feline lower urinary tract disease"],"prefix":"10.1111","volume":"51","author":[{"given":"Helo\u00edse Rangel","family":"Dinallo","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinics School of Veterinary Medicine and Animal Science \u2013 FMVZ, UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Universidade do Oeste Paulista \u2013 UNOESTE  Presidente Prudente Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriela P.","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics School of Veterinary Medicine and Animal Science \u2013 FMVZ, UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-6142","authenticated-orcid":false,"given":"Cec\u00edlia L.","family":"Santar\u00e9m","sequence":"additional","affiliation":[{"name":"Universidade do Oeste Paulista \u2013 UNOESTE  Presidente Prudente Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia M. C. F.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade do Oeste Paulista \u2013 UNOESTE  Presidente Prudente Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejane B.","family":"Brinholi","sequence":"additional","affiliation":[{"name":"Universidade do Oeste Paulista \u2013 UNOESTE  Presidente Prudente Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudney Pereira","family":"da Motta","sequence":"additional","affiliation":[{"name":"Faculdades Adamantinenses Integradas \u2013 FAI  Adamantina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M. S.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics School of Veterinary Medicine and Animal Science \u2013 FMVZ, UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Carlos P.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science \u2013 FMVZ, UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-5847","authenticated-orcid":false,"given":"Henry David M.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science \u2013 FMVZ, UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Falco","family":"de Brito","sequence":"additional","affiliation":[{"name":"Universidade do Oeste Paulista \u2013 UNOESTE  Presidente Prudente Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Melchert","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics School of Veterinary Medicine and Animal Science \u2013 FMVZ, UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-2426","authenticated-orcid":false,"given":"Priscylla Tatiana Chalfun","family":"Guimar\u00e3es\u2010Okamoto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics School of Veterinary Medicine and Animal Science \u2013 FMVZ, UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50206-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50200-7"},{"key":"e_1_2_8_4_1","first-page":"1828","volume-title":"Textbook of Veterinary Internal Medicine","author":"Westropp JL","year":"2005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118785546"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.10.006"},{"key":"e_1_2_8_7_1","first-page":"1483","volume-title":"Tratado de Medicina Interna de c\u00e3es e gatos","author":"Reche A","year":"2015"},{"key":"e_1_2_8_8_1","first-page":"26","article-title":"Controle diet\u00e9tico da DTUIF [Dietary control of DTUIF]","volume":"55","author":"King PH","year":"2005","journal-title":"Rev Cl\u00edn Vet S\u00e3o Paulo"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.06.007"},{"key":"e_1_2_8_10_1","first-page":"609","volume-title":"Medicina Interna de Pequenos Animais","author":"Nelson RW","year":"2010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.086"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15032"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12278"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00056.2003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(03)00119-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00019.x"},{"key":"e_1_2_8_17_1","unstructured":"GruysE;Toussaint MJM. Monitoring animal hygiene welfare and health by analytes of the acute phase reaction. Non\u2010specific assessment of infection inflammation bruising stress and starvation. Proceedings 19th ESVP Meeting; Thessaloniki Greece.2001;113\u2013131."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-370491-7.00005-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.04.009"},{"issue":"1","key":"e_1_2_8_20_1","first-page":"55","article-title":"Prote\u00ednas de fase aguda em c\u00e3es e gatos [acute phase proteins in dogs and cats]","volume":"17","author":"Santos IFC","year":"2010","journal-title":"Arq Ci\u00eanc Vet Zool"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12451"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638713486112"},{"key":"e_1_2_8_23_1","first-page":"97","article-title":"Prote\u00ednas de fase aguda: conceptos b\u00e1sico y principales aplicaciones cl\u00ednicas en medicina veterin\u00e1ria [Acute phase proteins: basic concepts and main clinical applications in veterinary medicine]","volume":"17","author":"Mart\u00ednez\u2010Subiela S","year":"2001","journal-title":"Anales de Vet da Murcia"},{"key":"e_1_2_8_24_1","first-page":"313","volume-title":"Manual de Cardiologia para C\u00e3es e Gatos","author":"Brown SA","year":"2002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420010909"},{"key":"e_1_2_8_26_1","first-page":"375","volume-title":"Manual de Terap\u00eautica Veterin\u00e1ria Consulta R\u00e1pida","author":"Andrade SMCF","year":"2017"},{"key":"e_1_2_8_27_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"Core Team R","year":"2018"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.06.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.65.545"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00012-4"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2016.10.006"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000082220.23903.1f"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.13047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:35:23Z","timestamp":1692992123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.13047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/vcp.13047"],"URL":"https:\/\/doi.org\/10.1111\/vcp.13047","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]},"assertion":[{"value":"2019-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}