{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:21:20Z","timestamp":1784938880939,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 13\u2010year\u2010old 4.6\u00a0kg castrated male Italian Greyhound was presented for evaluation of sneezing, bilateral epistaxis and mucoid nasal discharge of approximately 3\u00a0months duration. Severe periodontal disease was noted on physical exam. The patient\u2019s CBC was unremarkable. His biochemical profile revealed mild azotemia as well as mild electrolyte abnormalities. Rhinoscopy revealed a tan plaque present in the left dorsal meatus of the nasal cavity. Vigorous flushing yielded granular white particulates suspended in the saline, which were cytologically examined. Marked neutrophilic inflammation, a diverse bacterial population, and organisms consistent with amoebic trophozoites were identified. The remaining fluid was analyzed by PCR and sequencing, and <jats:italic>Entamoeba gingivalis<\/jats:italic> was identified. The dog\u2019s clinical signs improved dramatically after initiating treatment with clindamycin. Six weeks after diagnosis, a dental cleaning with multiple extractions was performed. Four weeks after the dental procedure, the dog was clinically normal. This report describes the clinical, hematologic, cytologic, and gross findings in a case of <jats:italic>Entamoeba gingivalis<\/jats:italic> infection in a dog.<\/jats:p>","DOI":"10.1111\/vcp.13064","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T06:58:46Z","timestamp":1646981926000},"page":"269-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nasal colonization by <i>Entamoeba gingivalis<\/i> in a 13\u2010year\u2010old Italian Greyhound"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2380-9374","authenticated-orcid":false,"given":"Nina K.","family":"Randolph","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-3648","authenticated-orcid":false,"given":"Camille A.","family":"McAloney","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ossiboff","sequence":"additional","affiliation":[{"name":"Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine University of Florida  Gainesville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9377-2445","authenticated-orcid":false,"given":"Jessica A.","family":"Hokamp","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.11.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.43179"},{"key":"e_1_2_5_4_1","first-page":"1","article-title":"Reassessing the role of Entamoeba gingivalis in periodontitis. Frontiers in Cellular and Infection","volume":"8","author":"Bonner M","year":"2008","journal-title":"Microbiology"},{"key":"e_1_2_5_5_1","unstructured":"Entamoeba gingivalis.CDC.govNovember 12 2019.https:\/\/www.cdc.gov\/dpdx\/entamoebagingivalis\/index.htmlAccessed March 29 2021."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27086-w"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/357301"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520901738"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jeu.12359"},{"issue":"3","key":"e_1_2_5_10_1","first-page":"171","article-title":"The effect of nonsurgical periodontal therapy on Trichomonas tenax and Entamoeba gingivalis in patients with chronic periodontitis","volume":"17","author":"Maybodi F","year":"2016","journal-title":"J Dent (Shiraz)"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.13064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:21:41Z","timestamp":1692876101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.13064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/vcp.13064"],"URL":"https:\/\/doi.org\/10.1111\/vcp.13064","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,10]]},"assertion":[{"value":"2021-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}