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Although changes in serum amyloid A (SAA) concentration have been linked with FP, its diagnostic accuracy remains unknown. We aimed to determine the accuracy of selected APPs in identifying cats with a high risk of FP based on increased fPLI. Serum fPLI was measured in cats (n\u00a0=\u00a052) that were presented to veterinary clinics with signs of lethargy and anorexia. The cats were divided into two groups (fPLI \u22643.5\u00a0\u03bcg\/L; n\u00a0=\u00a027 and fPLI &gt;3.5\u00a0\u03bcg\/L, n\u00a0=\u00a025), corresponding to low and high risks of FP. Serum albumin, globulin, haptoglobin (Hp), and SAA concentrations, as well as the albumin\u2010to\u2010globulin ratio (A\/G) and SAA\u2010to\u2010albumin (SAA\/A) ratios, were determined and compared between groups. The accuracy of these measurements was examined using a multivariable logistic regression model and receiver operator characteristic (ROC) curve analysis. SAA concentrations and SAA\/A ratios were significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.026 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.022) higher in cats with increased fPLI, with the area under ROC curve (AUROC) of 68.1% (CI 95%: 53.4%, 82.9%) and 68.6% (CI 95%: 54.0%, 83.2%), respectively. The logistic regression model combining SAA and A\/G had AUROC of 75.2% (CI 95%: 62.0%, 88.4%) for identifying cats with increased fPLI. SAA as a sole analyte or combined with A\/G had low to moderate accuracy in identifying anorexic, lethargic cats with increased fPLI. Serum albumin, globulin, and Hp concentrations had no discriminatory potential in these cats.<\/jats:p>","DOI":"10.1111\/vcp.13097","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:34:42Z","timestamp":1644546882000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Accuracy of acute\u2010phase proteins in identifying lethargic and anorectic cats with increased serum feline pancreatic lipase immunoreactivity"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9745-6113","authenticated-orcid":false,"given":"Magdalena Maria","family":"Krasztel","sequence":"first","affiliation":[{"name":"Division of Veterinary Epidemiology and Economics Institute of Veterinary Medicine, Warsaw University of Life Sciences\u2010SGGW  Warsaw 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