{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:55:57Z","timestamp":1787846157071,"version":"build-2784847793"},"reference-count":59,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C\u2010reactive protein (CRP) is a positive acute\u2010phase protein, serum concentrations of which increase nonspecifically in response to inflammatory processes of the dog. As such, it can aid in the identification of inflammatory disease and, maybe more importantly, the objective monitoring of disease progression. In dogs, CRP is frequently used to evaluate dogs with gastrointestinal diseases, such as chronic inflammatory enteropathies (also termed idiopathic inflammatory bowel disease), acute pancreatitis, canine parvovirus infection, hepatic disease, acute abdomen, and protein\u2010losing enteropathy. The diversity of the assays available to measure CRP in dogs is nearly as numerous as the diseases in which serum concentrations of this protein are increased. Assay methodologies include laser nephelometric immunoassays, enzyme\u2010linked immunosorbent assays, immunoturbidimetric assays, and time\u2010resolved immunofluorometric assays. While many of these assays are acceptable for clinical use in the dog, the same assay and analyzer should be used to measure a patient's CRP concentration longitudinally. By looking at the uses of CRP in human gastroenterology, including reducing the duration of antibiotic therapy, the veterinary profession can gain insight into novel ways in which serum CRP concentration measurements might be applied in veterinary medicine in the future.<\/jats:p>","DOI":"10.1111\/vcp.13100","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T03:27:58Z","timestamp":1641871678000},"page":"29-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Measurement and clinical applications of C\u2010reactive protein in gastrointestinal diseases of dogs"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-1130","authenticated-orcid":false,"given":"Marshal A.","family":"Covin","sequence":"first","affiliation":[{"name":"Gastrointestinal Laboratory Department of Small Animal Clinical Sciences Texas A&amp;M University College Station TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-2086","authenticated-orcid":false,"given":"Joerg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory Department of Small Animal Clinical Sciences Texas A&amp;M University College Station TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00019.x"},{"key":"e_1_2_7_3_1","first-page":"225","article-title":"Immunoanalytical characteristics of C\u2010reactive protein and high sensitivity C\u2010reactive protein","volume":"75","author":"Moutachakkir M","year":"2017","journal-title":"Ann Biol Clin"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15247"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02450.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12504"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02908.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01943.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2009.00462.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15065"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15525"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.2460\/javma.1992.201.10.1603","article-title":"Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987\u20131990)","volume":"201","author":"Jergens AE","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0296.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1534-6935.2004.04010.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.16-0009"},{"key":"e_1_2_7_16_1","first-page":"91","article-title":"Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention","volume":"7","author":"Mylonakis ME","year":"2016","journal-title":"Vet Med"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2010.00965.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.3.361"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9278-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063871002200308"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.246.1.91"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0729.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(03)00061-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117557"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.10.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2003.tb00316.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12199"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012799"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12810"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12264"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1415-2"},{"key":"e_1_2_7_32_1","first-page":"175","article-title":"Development and analytic validation of an enzyme\u2010linked immunosorbent assay for the measurement of canine pancreatic lipase immunoreactivity in serum","volume":"67","author":"Steiner JM","year":"2003","journal-title":"Can J Vet Res"},{"issue":"4","key":"e_1_2_7_33_1","first-page":"285","article-title":"Analytical validation of a point\u2010of\u2010care test and an automated immunoturbidimetric assay for the measurement of canine C\u2010reactive protein in serum","volume":"85","author":"Covin M","year":"2021","journal-title":"Can J Vet Res"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231445"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.70.127"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.68.1275"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.12935\/jvma1951.53.595"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.2003.00509.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-020-00549-9"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1065-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12150"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12576"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-006-3201-z"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172188"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2021.110221"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715575751"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/47.3.418"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.12.006"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0833-2"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063871102300109"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638720960065"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063871002200408"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.12.1281"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.12.014"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6348"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30142-5"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330600"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-011-0117-5"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14631"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16084"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.13100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:08:31Z","timestamp":1726448911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.13100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":59,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/vcp.13100"],"URL":"https:\/\/doi.org\/10.1111\/vcp.13100","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"2021-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}