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Abdominal imaging revealed the mass to be of small intestinal origin; consequently, an intestinal resection and anastomosis were performed without complication. The histopathologic diagnosis was a gastrointestinal stromal tumor, verified by immunohistochemical positivity to CD117 (KIT). Two weeks after discharge, the leukocytosis had resolved. Though the exact molecular mediator of the severe leukocytosis was undetermined, resolution following tumor removal suggests a paraneoplastic cause. To the authors' knowledge, this is the first reported case of probable paraneoplastic leukocytosis secondary to a gastrointestinal stromal tumor in the dog. Gastrointestinal tract imaging should be performed when this uncommon hematologic abnormality is present.<\/jats:p>","DOI":"10.1111\/vcp.13143","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T03:54:35Z","timestamp":1652154875000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Probable paraneoplastic leukocytosis in a dog with a gastrointestinal stromal tumor"],"prefix":"10.1111","volume":"52","author":[{"given":"Emily M.","family":"Gidcumb","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Virginia\u2010Maryland College of Veterinary Medicine Virginia Tech University Blacksburg Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-6441","authenticated-orcid":false,"given":"Timothy A.","family":"Bolton","sequence":"additional","affiliation":[{"name":"Department of 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