{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:05:31Z","timestamp":1747188331259,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 9\u2010week\u2010old puppy with refractory seizures and a dome\u2010shaped head presented to the Mississippi State College of Veterinary Medicine Specialty Center for suspected hydrocephalus. Computerized tomography (CT) findings included transtentorial herniation and an intra\u2010axial mass with dystrophic mineralization. Cerebrospinal fluid analysis revealed an increased nucleated cell count of 1100\/\u03bcl (RI\u2009&lt;\u20095\/\u03bcl), erythrocyte count of 2.2\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/\u03bcl, and markedly increased microprotein of 1939\u2009mg\/dl (RI\u2009&lt;\u200930\u2009mg\/dl). On cytologic examination of the CSF, numerous erythrophagocytic, and hemosiderin\u2010laden macrophages were observed, which indicated chronic active hemorrhage. Many neutrophils, macrophages, and lymphocytes that contained numerous intracytoplasmic, pleomorphic, bright yellow crystals were observed. Considering the ongoing hemorrhage, the crystals were presumed to be hematoidin. A biopsy with histopathology was performed on the intra\u2010axial mass, and the results were consistent with a vascular hamartoma. We speculate that the formation of these crystals was related to the ongoing hemorrhage associated with the vascular hamartoma. Identification of these crystals may be useful to aid in the identification of chronic hemorrhage associated with vascular malformations or lesions within the central nervous system.<\/jats:p>","DOI":"10.1111\/vcp.13153","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:48:45Z","timestamp":1660708125000},"page":"97-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CSF<\/scp>from a puppy with a cerebral vascular hamartoma"],"prefix":"10.1111","volume":"52","author":[{"given":"Marjorie J.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Population Medicine Mississippi State College of Veterinary Medicine Starkville Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany S.","family":"Baughman","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine Mississippi State College of Veterinary Medicine Starkville Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Shores","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine Mississippi State College of Veterinary Medicine Starkville Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan M. B.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine Mississippi State College of Veterinary Medicine Starkville Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela J.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine Mississippi State College of Veterinary Medicine Starkville Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy W.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine Mississippi State College of Veterinary Medicine Starkville Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-2640","authenticated-orcid":false,"given":"Matthew L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine Mississippi State College of Veterinary Medicine Starkville Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587701400206"},{"key":"e_1_2_3_3_1","first-page":"291","volume-title":"Pathologic Basis of Veterinary Disease","author":"Zachary JF","year":"2012"},{"key":"e_1_2_3_4_1","first-page":"627","volume-title":"Tumors in Domestic Animals","author":"Meuten DJ","year":"2017"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.09.009"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.12.006"},{"key":"e_1_2_3_7_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1939-1676.2006.tb02913.x","article-title":"Canine intracranial primary neoplasia: 173 cases (1986\u20102003)","volume":"20","author":"Snyder JM","year":"2006","journal-title":"J Vet Intern Med"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11-0201"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.38-1-108"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985820980707"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-625301"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010713"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896913510028"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05635.x"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.13153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.13153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T21:20:31Z","timestamp":1700947231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.13153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/vcp.13153"],"URL":"https:\/\/doi.org\/10.1111\/vcp.13153","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"type":"print","value":"0275-6382"},{"type":"electronic","value":"1939-165X"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}