{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:41:44Z","timestamp":1776897704453,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Viscoelastic coagulation monitor (VCM\u2010Vet) is a point\u2010of\u2010care device that has been used to characterize hemostatic abnormalities in sick pets but has not been validated in veterinary patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to compare VCM\u2010Vet and thromboelastography (TEG) in sick dogs with suspected disorders of hemostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Duplicate VCM\u2010Vet tests using untreated native blood performed concurrently on two VCM\u2010Vet machines, and simultaneous TEG tests were performed (one citrated native (CN), and one activated with tissue factor (TF) at a 1:3600 dilution). Each VCM\u2010Vet result was compared with both TF\u2010activated and CN TEG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three dogs were enrolled. Eleven cases displayed apparent hyperfibrinolysis. Spearman correlation coefficients for individual VCM\u2010Vet devices and CN and TF TEG were obtained between R and CT values and ranged from 0.21 to 0.27, CFT and K (<jats:italic>r<\/jats:italic>\u00a0=\u20090.60\u20130.67), angles (<jats:italic>r<\/jats:italic>\u00a0=\u20090.51\u20130.62), and MCF and MA (<jats:italic>r<\/jats:italic>\u00a0=\u20090.85\u20130.87). Comparison of the two VCM\u2010Vet devices displayed positive correlations for all clot formation parameters with Lin's concordance correlation coefficients of 0.75\u20130.95. Variable lysis parameter agreement existed between the VCM\u2010Vet devices and VCM\u2010Vet and TEG. When samples were classified as hypercoagulable or coagulopathic, VCM\u2010Vet had a low positive predictive value (17\u201333%) for the detection of hypercoagulable states and a moderate negative predictive value (64\u201374%) for the detection of coagulopathy as defined by TEG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VCM\u2010Vet and TEG had variable correlations in clot formation values and a strong correlation for final clot strength. More information is needed to make conclusions about the lysis parameters. Artifact in the fibrinolysis portion of the test can confound the interpretation of VCM\u2010Vet results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.13198","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T06:29:20Z","timestamp":1676615360000},"page":"217-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of a viscoelastic point\u2010of\u2010care coagulation monitor with thromboelastography in sick dogs with hemostatic abnormalities"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5554-2817","authenticated-orcid":false,"given":"Yekaterina","family":"Buriko","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-4443","authenticated-orcid":false,"given":"Nolan V.","family":"Chalifoux","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Clarkin\u2010Breslin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah C.","family":"Silverstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine Veterinary Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-016-0308-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002206"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.09.029"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13068"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.09.183"},{"issue":"2","key":"e_1_2_6_8_1","first-page":"CD010438","article-title":"Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding","volume":"2015","author":"Hunt H","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11091642"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15478"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12926"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12916"},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"Viscoelastic coagulation monitor (VCMVet) reference intervals and sex differences in mature adult mice","volume":"8","author":"Rigor RR","year":"2021","journal-title":"Acta Haematol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12049"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13129"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001380"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1704719"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12144"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001032"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002545"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X18811731"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32833113e9"},{"key":"e_1_2_6_23_1","unstructured":"VCM Vet\u2122 Operator's Manual Entegrion Inc.1007 Slater Road Suite 170 Durham NC 27703 USA; 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