{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:16Z","timestamp":1787016076384,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myeloma\u2010related disorders, including multiple myeloma, extramedullary plasmacytoma, and solid osseous plasmacytoma, are rare in horses. Clinical complaints for myeloma\u2010related disorders are nonspecific, and when present, M\u2010protein location is more variable on protein electrophoresis in horses relative to dogs and cats. Here, we describe a case of a 15\u2010year\u2010old Thoroughbred mare who presented with recurrent blepharitis. Marked hyperglobulinemia was an incidental finding on routine hematologic and biochemical testing. Bone marrow aspiration consisted of &gt;30% plasma cells, and serum protein electrophoresis demonstrated a monoclonal gammopathy in the alpha 2 fraction leading to a diagnosis of multiple myeloma. Immunofixation and radial immunodiffusion confirmed the presence of an IgG M\u2010protein. Based on a restricted peak in the alpha 2 location, the specific M\u2010protein is suspected to be IgG(T), an IgG isotype unique to horses. M\u2010protein migration in horses is variable relative to dogs and cats, yet immunofixation can still be used to identify equine IgG M\u2010protein isotypes. The unique clinical presentation in this case also serves as a reminder to consider neoplasia in horses with unusual or nonspecific clinical signs.<\/jats:p>","DOI":"10.1111\/vcp.13227","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T22:54:36Z","timestamp":1685400876000},"page":"514-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiple myeloma presenting as blepharitis in a horse"],"prefix":"10.1111","volume":"52","author":[{"given":"Allison M.","family":"Hayes","sequence":"first","affiliation":[{"name":"Department of Diagnostic Medicine\/Pathobiology Kansas State University Manhattan Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-4087","authenticated-orcid":false,"given":"Brandy","family":"Kastl","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine\/Pathobiology Kansas State 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