{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:47:14Z","timestamp":1779162434073,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007103","name":"Semnan University","doi-asserted-by":"publisher","award":["139807061130"],"award-info":[{"award-number":["139807061130"]}],"id":[{"id":"10.13039\/501100007103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Changes in platelet indices in naturally occurring type I diabetes mellitus (T1DM) have been described in several studies. In this study, platelet indices such as platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and MPV to PLT ratio were investigated according to diabetic duration after streptozotocin (STZ)\u2010induced T1DM, as well as for their correlation with glucose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty healthy adult Wistar rats were randomly assigned to four experimental groups of ten (5 rats of each sex), including the control group, the 7, 14, and 28\u2009days diabetic groups (D7, D14, and D28, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In diabetic groups, plasma glucose was significantly higher than in control (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). D7, D14, and D28 groups presented significantly lower PLT than the control (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090. 01). A significant decrease in PCT was observed in D14 and D28 females (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Mean platelet volume was significantly higher in the D28 group than in to control. D28 females also showed a significant difference in PLT, MPV, and the MPV\u2010to\u2010PLT ratio compared with D7 females (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A comparison between D28 females and males showed a significant difference in PDW (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Both females and males showed a significant correlation between glucose and PLT, PCT, MPV, and the MPV\u2010to\u2010PLT ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Platelet indices change significantly with the duration of diabetes compared with the baseline values, and female and male rats did not have significant differences in platelet indices in any period except the 28\u2009days.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.13229","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T03:10:14Z","timestamp":1679973014000},"page":"236-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Duration of the diabetic state altered platelet indices from baseline values in a streptozotocin\u2010induced rat model for type 1 diabetes mellitus"],"prefix":"10.1111","volume":"52","author":[{"given":"Sahar","family":"Oudeh","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pathobiology Semnan University  Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Javahery\u00a0Vayghan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pathobiology Semnan University  Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-3720","authenticated-orcid":false,"given":"Mahmood","family":"Ahmadi\u2010hamedani","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Clinical Sciences Semnan University  Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00443-4"},{"key":"e_1_2_8_3_1","first-page":"253","article-title":"Streptozotocin\u2010a diabetogenic agent in animal models","volume":"3","author":"Goud BJ","year":"2015","journal-title":"Int J pharm Pharm Res"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-12-60"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.78"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1985.tb03182.x"},{"key":"e_1_2_8_7_1","first-page":"600e6","article-title":"The role of mean platelet volume as a predicting factor of asymptomatic coronary artery disease. 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