{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:31:37Z","timestamp":1785382297365,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Phenobarbital (PB) is used as a first\u2010line treatment for recurrent epileptic seizures in cats. While hematologic abnormalities are well\u2010known side effects of antiepileptic therapy with PB in humans and dogs, little is known about such alterations in cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this retrospective study was to investigate the prevalence and clinical relevance of cytopenia during PB treatment in cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center, retrospective clinical study, 69 cats\u2014with suspected idiopathic epilepsy admitted to the Small Animal Clinic of the University of Veterinary Medicine in Vienna (VMU)\u2014were included. A complete blood count for each patient was performed, and changes in hematocrit, leukocytes, neutrophils, and thrombocytes were documented and graded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three out of 69 cats (76.8%) showed cytopenias with a reduction of at least one cell fraction during PB treatment. The most frequent change was neutropenia (60%), followed by leukopenia (49.3%), thrombocytopenia (24.1%), and anemia (20.3%). Most of the changes were mild or moderate; only one patient (1.5%) showed severe leukopenia and neutropenia, and one was a life\u2010threatening neutropenia (1.5%) with a serum PB concentration within or even below the therapeutic range. These patients did not present with clinical symptoms other than those related to epileptic episodes. Cats who received combination therapy showed lower hematocrits than those who received monotherapy. A tendency for leukocytes and neutrophils to decrease during PB treatment was also seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Blood cytopenias may frequently occur in cats on chronic PB therapy, even when serum drug levels are within the therapeutic range. However, clinical signs are typically mild to moderate and rarely severe.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.13259","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:24:44Z","timestamp":1695032684000},"page":"601-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A retrospective evaluation of phenobarbital\u2010induced hematologic changes in 69 cats"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-2109","authenticated-orcid":false,"given":"Anna","family":"Doh\u00e1ny","sequence":"first","affiliation":[{"name":"Department for Companion Animals and Horses, Small Animal Clinic, Internal Medicine University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-4598","authenticated-orcid":false,"given":"Abigail","family":"Guija\u2010de\u2010Arespacochaga","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Clinical Pathology Platform University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fux","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Silberbauer","sequence":"additional","affiliation":[{"name":"Department for Companion Animals and Horses, Small Animal Clinic, Internal Medicine University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-6970","authenticated-orcid":false,"given":"\u00c1kos","family":"P\u00e1kozdy","sequence":"additional","affiliation":[{"name":"Department for Companion Animals and Horses, Small Animal Clinic, Internal Medicine University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1386-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12464627"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0464-z"},{"key":"e_1_2_7_5_1","unstructured":"Hab\u00f6ckG PakozdyA.H\u00e4matologische Abweichungen w\u00e4hrend der Phenobarbital\u2010Therapie Beim Hund Material Und Methoden.2012:99 18\u201025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102158"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.283"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20924925"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055116920916945"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X211037431"},{"key":"e_1_2_7_11_1","first-page":"1264","volume-title":"Innere Medizin Der Kleintiere. 6. 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