{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:32:34Z","timestamp":1784313154030,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophilic effusions are commonly defined as effusions with \u226510% eosinophils. Eosinophilic cavitary effusions are infrequently observed in cats, with few case reports comprising the majority of the recent literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to review disease associations of cats with eosinophilic cavitary effusions and to assess if a lower threshold of eosinophils (5%<jats:italic>\u2013<\/jats:italic>9%) may warrant consideration of similar etiologies associated with effusions with \u226510% eosinophils.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cytology reports were retrospectively reviewed for all feline cavitary effusions submitted for fluid analysis from 2010 to 2020 at a veterinary teaching hospital. Cases were included if the manual leukocyte differential included \u22655% eosinophils and separated into 5%<jats:italic>\u2013<\/jats:italic>9% and \u226510% eosinophils groups. Patient records were reviewed for associated medical conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 669 effusions were submitted from 579 cats; 50 effusions from 48 cats had a leukocyte differential with \u22655% eosinophils. The eosinophil proportion was \u226510% in 22 cats; the most common underlying cause was neoplasia (10\/22, 45%), followed by inflammatory disease (4\/22, 18%), cardiac disease (3\/22, 14%), suspect neoplasia (3\/22, 14%), and undetermined (2\/22, 9%). The underlying causes for the 26 cats with 5%<jats:italic>\u2013<\/jats:italic>9% eosinophils were similar; neoplasia (8\/26, 31%), cardiac disease (6\/26, 23%), inflammatory disease (4\/26, 15%), suspect neoplasia (3\/26, 12%), undetermined (3\/26, 12%), and idiopathic chylothorax (2\/26, 8%). Cats with eosinophil proportions \u226510% in the fluid exhibited peripheral eosinophilia more frequently (35%) compared to those with 5%\u20139% eosinophils (5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consistent with the current literature, neoplasia, particularly lymphoma, remains a primary consideration for cats with eosinophilic effusions. Previously unreported associated diseases included cardiovascular and inflammatory disorders. Our findings suggest an eosinophil differential of 5%<jats:italic>\u2013<\/jats:italic>9% is seen with similar etiologies considered for classically defined eosinophilic effusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.13295","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:57:36Z","timestamp":1696409856000},"page":"681-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic cavitary effusions in cats: 48 cases (2010\u20132020)"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-0648","authenticated-orcid":false,"given":"Meagan A.","family":"Wheatley","sequence":"first","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-2995","authenticated-orcid":false,"given":"Devorah M.","family":"Stowe","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-0393","authenticated-orcid":false,"given":"Hiroyuki","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"issue":"11","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2460\/javma.1993.202.11.1873","article-title":"Eosinophilic pleural or peritoneal effusions in dogs and cats: 14 cases (1986\u20131992)","volume":"202","author":"Fossum TW","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18816489"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.253.2.181"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-013-1684-x"},{"issue":"5","key":"e_1_2_7_6_1","first-page":"556","article-title":"Pleural effusion as a sequela to aelurostrongylosis in a cat","volume":"185","author":"Miller BH","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1994.tb03405.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-31-6-484"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2002.tb00091.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0064"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2021.12.009"},{"key":"e_1_2_7_12_1","volume-title":"Canine and Feline Cytopathology: A Color Atlas and Interpretation Guide","author":"Boes KM","year":"2022"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2021.03.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1959.tb00186.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.1.106"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90542-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200609000-00011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327200"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01767-1"},{"key":"e_1_2_7_20_1","unstructured":"HarmsenW.Ueber die Weissen Zellen in Lebenden und im Defibrinirten Menschlichen Blute; Nebst einem Anhange ueber die Weissen Blutzellen im Fieberfreien Haematothorax. 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