{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:44:10Z","timestamp":1775817850456,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Himalayan marmot (<jats:italic>Marmota himalayana<\/jats:italic>) plays a reservoir role in the epidemiology of brucellosis. However, the changes in blood biochemical parameters are still unclear in <jats:italic>Brucella<\/jats:italic>\u2010seropositive marmots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present study was designed to explore the hematologic and biochemical variable changes in <jats:italic>Brucella<\/jats:italic>\u2010seropositive marmots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples were collected from the dorsalis pedis vein of Himalayan marmots (24 <jats:italic>Brucella<\/jats:italic>\u2010seropositive marmots and 24 <jats:italic>Brucella<\/jats:italic>\u2010free marmots). Ten hematologic and 10 serum biochemical variable examinations were performed and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that leukocyte, platelet, neutrophil, and lymphocyte counts significantly increased, while the level of carbon dioxide combining power decreased in <jats:italic>Brucella<\/jats:italic>\u2010infected marmots. These findings indicate that <jats:italic>Brucella<\/jats:italic> triggers an immune response in Himalayan marmots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides a preliminary investigation of the changes in blood biochemical analytes in <jats:italic>Brucella<\/jats:italic>\u2010infected marmots. The interaction between <jats:italic>Brucella<\/jats:italic> infection and blood biochemical indices in Himalayan marmots should be further explored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.13297","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T04:10:02Z","timestamp":1695096602000},"page":"732-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of hematologic and serum biochemical variables in <i>Brucella<\/i>\u2010infected and <i>Brucella<\/i>\u2010free adult Himalayan marmots (<i>Marmota himalayana<\/i>)"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-022X","authenticated-orcid":false,"given":"Nan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Basic Medicine, School of Medicine Shihezi University  Shihezi City Xinjiang People's Republic of China"},{"name":"NHC Key Laboratory of Prevention 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