{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:33:30Z","timestamp":1783510410705,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 10\u2010year\u2010old neutered male Maltese dog was presented for an investigation of lymphocytosis. The dog was up\u2010to\u2010date on vaccinations and deworming. Physical examination did not reveal any significant abnormalities. A complete blood cell count (CBC) showed mild leukocytosis with moderate lymphocytosis, basophilia, and moderate neutropenia, but no significant left shift or toxic change. Serum biochemistry and urinalysis were unremarkable. All performed tests for infectious agents common in this geographical region were negative. No significant abnormalities were found on abdominal ultrasound examination. Multiparametric flow cytometry of peripheral blood showed a CD8<jats:sup>+<\/jats:sup> T\u2010cell lymphocytosis, and PCR for antigen receptor rearrangement revealed a clonal expansion of the T\u2010cell receptor gamma chain genes. A clinical diagnosis of chronic lymphocytic leukemia (CLL) was made, and follow\u2010up was recommended. On Day 48 post\u2010presentation, the CBC showed mild non\u2010regenerative anemia (NRA), moderate leucocytosis due to moderate to marked lymphocytosis, basophilia, and a marked increase in hyposegmented neutrophils with mild toxic change in the absence of neutrophilia or neutropenia. Treatment with chlorambucil and prednisolone was initiated. On Days 87 and 197 post\u2010presentation, the CBC showed mild NRA, with progressively decreasing numbers of hyposegmented neutrophils. The dog remained without clinical signs. Basophilia and probable pseudo\u2010Pelger\u2013Hu\u00ebt anomaly were possibly secondary to CLL. To the authors' knowledge, this is the first report of these two hematologic conditions secondary to CLL in dogs. Recognition of a pseudo\u2010Pelger\u2013Hu\u00ebt anomaly is clinically relevant to avoid misinterpretation as a marked left shift due to severe inflammation and prevent unnecessary urgent therapeutic actions.<\/jats:p>","DOI":"10.1111\/vcp.13347","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T03:05:36Z","timestamp":1713236736000},"page":"202-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Presumed pseudo\u2010Pelger\u2013Hu\u00ebt anomaly and basophilia secondary to chronic lymphocytic leukemia in a dog"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-8668","authenticated-orcid":false,"given":"Javier","family":"Mart\u00ednez\u2010Caro","sequence":"first","affiliation":[{"name":"Servei d'Hematologia Cl\u00ednica Veterin\u00e0ria, Departament de Medicina i Cirurgia Animals, Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma 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