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In both cases, biochemical analysis was consistent with rhabdomyolysis. Additionally, a markedly increased measured serum bicarbonate concentration and negative calculated anion gap were observed. As these biochemical abnormalities were not expected and deemed incompatible with life, an interference with the analyzer measurement of bicarbonate involving marked increases in pyruvate and lactate dehydrogenase (LDH) following myocyte injury was suspected. Venous blood gas analysis calculated bicarbonate concentration and anion gap were within reference interval, while measured LDH activity was markedly increased. These findings supported an analyzer\u2010generated interference. This is the first published report of a previously described chemistry analyzer interference of markedly increased LDH activity with serum bicarbonate concentration measurement in dogs and cats. Awareness of this interference is important, particularly in the emergency setting, as it may influence case management.<\/jats:p>","DOI":"10.1111\/vcp.13350","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T02:20:16Z","timestamp":1714789216000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spurious hyperbicarbonatemia and a negative anion gap in a cat and a dog with severe rhabdomyolysis"],"prefix":"10.1111","volume":"53","author":[{"given":"Jennifer","family":"Bouschor","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine University of Minnesota  Saint Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-1552","authenticated-orcid":false,"given":"Christopher 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