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Biochemical analysis using a Beckman Coulter AU480 demonstrated marked increases in creatine kinase and aspartate aminotransferase, indicative of severe muscle injury, with concurrent presumptive myoglobinuria on urinalysis. A marked, non\u2010physiologic increase in measured bicarbonate and resultant negative anion gap was documented; however, calculated bicarbonate obtained via a point\u2010of\u2010care blood gas analyzer was within normal limits. Laboratory error due to interference by lactate dehydrogenase was suspected and supported by the results of subsequent biochemical testing. Artifactual increases in bicarbonate have been documented in cases of rhabdomyolysis in horses, cows, and a bird. However, to the best of the authors' knowledge, this is the first report to demonstrate this spurious change in a cat.<\/jats:p>","DOI":"10.1111\/vcp.13371","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:39:44Z","timestamp":1718350784000},"page":"315-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artifactually increased serum bicarbonate in a cat with rhabdomyolysis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6894-9199","authenticated-orcid":false,"given":"Zoe R.","family":"Wynter","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine Queen's Veterinary School Hospital, University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Ruane","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Queen's Veterinary School Hospital, University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre J.","family":"Kortum","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Queen's Veterinary School Hospital, University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassia H. 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