{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:38:03Z","timestamp":1770748683545,"version":"3.50.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Packed RBC (pRBC) transfusions are often necessary to enhance organ perfusion and tissue oxygenation in cases of severe anemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to describe changes in acid\u2013base and biochemical parameters in dogs after transfusion of pRBC and potential effects on the outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective observational study included anemic dogs requiring pRBC transfusions. Venous blood gas and electrolytes were measured pre\u2010transfusion and repeated within 1\u2009h post\u2010transfusion. Signalment, pre\u2010existing conditions and underlying disease(s), number of days spent of hospitalization, the quantity of transfused pRBC units, and the outcome were also recorded. Associations between analytical values and all other parameters before and after transfusion were assessed using the Wilcoxon test. A generalized linear model was generated for each of the blood gas parameters post\u2010transfusion, including the pre\u2010transfusion values and the characteristics of the animal as fixed effects. The effect of the blood gas parameters on the mortality and hospitalization length was assessed using logistic regression and generalized linear models, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six dogs with different causes of anemia were included in the study, with dogs remaining hospitalized for a median of 3\u2009days (range: 0\u201311). Pre\u2010transfusion heart rate, respiratory rate, Angap, base excess, and lactate were higher than post\u2010transfusion values. Post\u2010transfusion results showed an increase in hematocrit, hemoglobin, HCO<jats:sub>3<\/jats:sub>\u2010, PCO<jats:sub>2<\/jats:sub>, tCO<jats:sub>2<\/jats:sub>, and chloride. Pre\u2010transfusion hypophosphatemia and receiving an increased volume of transfused pRBC were associated with a longer hospital stay, while higher pre\u2010transfusion lactate values were associated with higher mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>pRBC transfusion in anemic dogs was associated with an improvement in perfusion and acid\u2013base parameters. Pre\u2010transfusion lactate may be an indicator of mortality in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.13379","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T02:10:21Z","timestamp":1727057421000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acid\u2013base and electrolyte changes in dogs after packed red blood cell transfusion"],"prefix":"10.1111","volume":"53","author":[{"given":"P.","family":"Bou","sequence":"first","affiliation":[{"name":"Emergency and Critical Care Service, Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona  Barcelona Bellaterra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Mesa","sequence":"additional","affiliation":[{"name":"Animal Blood Bank  Barcelona Spain"},{"name":"Internal Medicine Service A\u00fana Especialidades Veterinarias  Paterna (Valencia) Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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