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LR<\/jats:styled-content>\u2010FFP<\/jats:styled-content> was further separated into LR<\/jats:styled-content>\u2010CRYO<\/jats:styled-content> and LR<\/jats:styled-content>\u2010CPP<\/jats:styled-content>. LR<\/jats:styled-content>\u2010CRYO<\/jats:styled-content> was frozen, thawed, and divided into two bags, one refrigerated for 24\u2009h and one refrozen for 7\u2009days. Factor VIII<\/jats:styled-content> (FVIII<\/jats:styled-content>) and X (FX<\/jats:styled-content>) activity, prothrombin time, activated partial thromboplastin time, antithrombin III<\/jats:styled-content> (ATIII<\/jats:styled-content>) activity (ATA<\/jats:styled-content>), total protein, albumin, fibrinogen, and D\u2010dimer concentration, and von Willebrand Factor (vWF<\/jats:styled-content>) activity were measured in LR<\/jats:styled-content>\u2010FP<\/jats:styled-content>, LR<\/jats:styled-content>\u2010CRYO<\/jats:styled-content>, LR<\/jats:styled-content>\u2010CPP<\/jats:styled-content>, refrigerated, and refrozen LR<\/jats:styled-content>\u2010CRYO<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>FVIII activity was higher in LR\u2010CRYO (p<\/jats:italic>\u2009=\u20090.0001) versus LR\u2010FP. vWF activity (p<\/jats:italic>\u2009<\u20090.0001) and fibrinogen concentration (p<\/jats:italic>\u2009=\u20090.0012) were lower in LR\u2010CPP versus LR\u2010FP. FX activity was higher in LR\u2010CPP (p<\/jats:italic>\u2009<\u20090.0001) and LR\u2010FP (p<\/jats:italic>\u2009=\u20090.0002) versus LR\u2010CRYO, and albumin concentration was higher in LR\u2010CPP versus LR\u2010FP (p<\/jats:italic>\u2009<\u20090.0001) and LR\u2010CRYO (p<\/jats:italic>\u2009<\u20090.0001). No statistically significant difference was found in refrigerated or refrozen LR\u2010CRYO as compared with LR\u2010CRYO, excluding ATA, which was lower (p<\/jats:italic>\u2009=\u20090.0062) in refrigerated LR\u2010CRYO.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Because the concentration of FVIII is higher in LR\u2010CRYO than in LR\u2010FP, LR\u2010CRYO is a possible component therapy when this factor is deficient. Since no statistically significant difference was found in refrozen LR\u2010CRYO as compared with LR\u2010CRYO, LR\u2010CRYO can be frozen after thawing for reuse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.70017","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T08:03:27Z","timestamp":1750061007000},"page":"120-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Hemostatic Activity in Canine Leukoreduced Cryoprecipitate, Cryopoor Plasma, and Fresh Plasma"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-907X","authenticated-orcid":false,"given":"Roberta","family":"Perego","sequence":"first","affiliation":[{"name":"Veterinary Transfusion Research Laboratory (REVLab), Department of Veterinary Medicine and Animal Science (DIVAS) University of Milan Lodi 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