{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:40:47Z","timestamp":1773002447634,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A 7\u2010year\u2010old female intact pug was presented for a six\u2010month history of cough, dyspnea, and exercise intolerance. Treatment with fenbendazole was initiated 3\u2009days before referral based on a positive blood quantitative PCR for <jats:italic>Angiostrongylus vasorum (A. vasorum)<\/jats:italic> without improvement of the clinical signs. The dog lived in Belgium with a traveling history to Corsica and Canada. On physical examination, the dog was tachypneic with expiratory dyspnea. Mild non\u2010regenerative anemia, monocytosis, eosinophilia, and basophilia were identified on hematology. Biochemistry revealed hyperproteinemia due to hyperglobulinemia. The protein capillary zone electrophoresis (CZE) identified a restricted polyclonal (or oligoclonal) peak in the beta\u2010globulin region and a tall and narrow peak in the gamma\u2010globulin region, suggestive of either restricted polyclonal or monoclonal gammopathy. Further diagnostic investigations included thoracic radiographs, echocardiography, abdominal ultrasound, urinalysis, snap test 4Dx, <jats:italic>Leishmania<\/jats:italic> spp. serology, and <jats:italic>Leishmania<\/jats:italic> spp. PCR on bone marrow aspirates. Severe proteinuria was noted with a urine protein to creatinine ratio (UPCR) of 7.54. No infectious agents other than <jats:italic>A. vasorum<\/jats:italic> were identified. Treatment with fenbendazole was pursued for 7\u2009days, followed by a spot\u2010on application of imidacloprid\/moxidectin combined with tapering the anti\u2010inflammatory dose of steroids, with complete resolution of the respiratory signs. At 1\u2010month recheck, hyperglobulinemia and proteinuria completely resolved, and the thoracic radiographic images improved. To the authors' knowledge, this case is the first to describe such a gammopathy associated with chronic angiostrongylosis.<\/jats:p>","DOI":"10.1111\/vcp.70026","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T12:16:47Z","timestamp":1754050607000},"page":"258-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unusual Electrophoretic Pattern in a Dog Infected With <i>Angiostrongylus vasorum<\/i>"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9417-9206","authenticated-orcid":false,"given":"Alice","family":"K\u00e9fer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine CHV OnlyVet  Saint\u2010Priest France"},{"name":"Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7899-9879","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Machiels","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Vincken","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Pitchford","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Group  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9lodie","family":"Roels","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2004.11.009"},{"key":"e_1_2_4_3_1","first-page":"181","article-title":"Canine Angiostrongylosis: Recent Advances in Diagnosis, Prevention, and Treatment","volume":"5","author":"Di Cesare A.","year":"2014","journal-title":"Veterinary Medicine"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.11.014"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.01.025"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105097"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12419"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13065"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.10.018"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12760"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-010-9365-6"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1987.tb01980.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03223.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.5326\/0380135"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1992.201.08.1233"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb01098.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.5326\/0450296"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12993"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12940"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13399"},{"issue":"1","key":"e_1_2_4_21_1","first-page":"9","article-title":"Benign Monoclonal Gammopathy in a Dog Exhibiting a Low Antibody Titer to Ehrlichia canis","volume":"2","author":"Ng S.","year":"2010","journal-title":"Journal of Clinical Immunology and Immunopathology Research"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2414-4"},{"key":"e_1_2_4_23_1","first-page":"3196","article-title":"Assessment of Both IDEXX Angio Detect on Bronchoalveolar Lavage Fluid and Angiostrongylus vasorum Quantitative Polymerase Chain Reaction on EDTA Blood in Dogs That Tested Negative for IDEXX Angio Detect on EDTA Blood","volume":"35","author":"Roels E.","year":"2021","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"e_1_2_4_24_1","first-page":"45","article-title":"Recent Advances in the Epidemiology, Clinical and Diagnostic Features, and Control of Canine Cardio\u2010Pulmonary Angiostrongylosis","volume":"27","author":"Elsheikha H. 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