{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:44:07Z","timestamp":1768743847086,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015900","name":"OVC Pet Trust","doi-asserted-by":"publisher","award":["300\u2010022000\u2010055984\u201000000"],"award-info":[{"award-number":["300\u2010022000\u2010055984\u201000000"]}],"id":[{"id":"10.13039\/100015900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Regular blood sampling to monitor RBC mass in anemic cats can exacerbate anemia. Laboratory\u2010based reporting can delay clinical decisions. A hand\u2010held hemoglobinometer, HemoCue Hb 201<jats:sup>+<\/jats:sup> (HC\u2010201), requires only one drop of blood (10\u2009\u03bcL) and provides results within 1\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This preliminary study aimed to evaluate the utility of HC\u2010201 in cats and investigate the impact of potential interferents on its performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and fifty\u2010four venous blood samples in EDTA from 93 cats were analyzed. Hemoglobin concentration was measured once using an ADVIA 2120 analyzer and compared to the mean of 2\u20133 replicate measurements from an HC\u2010201. Agreement and systematic bias between HC\u2010201 and ADVIA results, along with precision between HC\u2010201 replicates, were assessed using Lin's concordance correlation coefficient, non\u2010parametric Bland\u2013Altman, Passing\u2010Bablok regression, and intraclass correlation coefficient. The performance of HC\u2010201 in the presence of anemia, leukocytosis, azotemia, lipemia, icterus, hemolysis, and peripheral versus jugular venipunctures was assessed using Wilcoxon rank\u2010sum tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Passing\u2010Bablok analysis revealed a significant constant bias (intercept\u2009=\u2009\u22122.242, 95% CI: \u22124.042 to \u22120.667) but no significant proportional bias (slope\u2009=\u20091.015, 95% CI: 1.000\u20131.032). HC\u2010201 demonstrated excellent agreement (<jats:italic>\u03c1<\/jats:italic><jats:sub>c<\/jats:sub>\u2009=\u20090.989) and precision (ICC\u2009=\u20090.997) with a median bias of \u22120.67\u2009g\/L (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). The total observed error was 3.02%, within the allowable limits defined by international standards. Neither anemia, leukocytosis, azotemia, lipemia, nor venipuncture site influenced HC\u2010201 measurements. Samples with icterus and hemolysis were insufficient in number for statistical comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This preliminary study indicates that HC\u2010201 offers reliable point\u2010of\u2010care monitoring for hemoglobin concentration in cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vcp.70035","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:54:01Z","timestamp":1752569641000},"page":"211-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Method Comparison and Investigation of Interference Variables of a Hand\u2010Held Hemoglobinometer(<scp>HemoCue<\/scp> Hb 201<sup>+<\/sup>) in Cats"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3184-5962","authenticated-orcid":false,"given":"Yuqing","family":"Sun","sequence":"first","affiliation":[{"name":"Departments of Clinical Studies 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