{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:10:33Z","timestamp":1778908233994,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008004","name":"Kastamonu \u00dcniversitesi","doi-asserted-by":"publisher","award":["K\u00dcBAP\u201001\/2023\u201032"],"award-info":[{"award-number":["K\u00dcBAP\u201001\/2023\u201032"]}],"id":[{"id":"10.13039\/501100008004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["1919B012303374"],"award-info":[{"award-number":["1919B012303374"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The periparturient period in dairy cows is marked by negative energy balance (NEB), resulting in metabolic stress and an increased risk of postpartum diseases. Accurate assessment of NEB through blood \u03b2\u2010hydroxybutyrate (\u03b2\u2010OHB) levels is essential for effective herd management. Point\u2010of\u2010care (POC) devices, such as the CentriVet blood ketone monitoring system, offer a practical alternative to laboratory methods for measuring \u03b2\u2010OHB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic and analytical performance of the CentriVet blood ketone monitoring system compared to a laboratory reference method for measuring blood \u03b2\u2010OHB concentration in postpartum dairy cattle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 105 postpartum dairy cows from two farms were included. Blood samples were analyzed for \u03b2\u2010OHB using both CentriVet and a reference enzymatic method. Passing\u2013Bablok regression, Bland\u2013Altman plots, and kappa statistics were used to assess agreement. Diagnostic accuracy metrics (sensitivity, specificity, PPV, NPV, and accuracy) were calculated at a cut\u2010off value of \u2265\u20091.2\u2009mmol\/L. An optimized cut\u2010off value was determined via ROC curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CentriVet demonstrated a moderate correlation with the reference method (Spearman's\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.701,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Passing\u2013Bablok regression revealed proportional bias, and Bland\u2013Altman analysis indicated a mean bias of \u22120.4\u2009mmol\/L. Diagnostic metrics at \u2265\u20091.2\u2009mmol\/L showed 100% sensitivity, 68.09% specificity, and 71.4% accuracy. ROC analysis yielded an optimized cut\u2010off of &gt;\u20091.5\u2009mmol\/L, improving specificity (95.7%) but reducing sensitivity (81.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While CentriVet offers practical benefits, its diagnostic performance is limited for accurately identifying hyperketonemia in postpartum dairy cattle.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vcp.70079","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:40:21Z","timestamp":1768624821000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Diagnostic and Analytical Performance of the\n                    <scp>CentriVet<\/scp>\n                    Blood Ketone Monitoring System in Postpartum Dairy Cattle"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-0236","authenticated-orcid":false,"given":"Kenan \u00c7.","family":"T\u00fcmer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine Kastamonu University  Kastamonu T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tar\u0131k","family":"\u015eafak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine Kastamonu University  Kastamonu T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130sa","family":"\u015eekercio\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Kastamonu University  Kastamonu T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper O.","family":"Akba\u015f","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Kastamonu University  Kastamonu T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-024-01013-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2013.03.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2013.04.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016-11077"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/dairy2040052"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.24425\/pjvs.2019.129964"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-021-02955-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2006.tb00131.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.08.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(00)00115-X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-7121"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016-11097"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2527\/jam2016-0053"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13223"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2011.010"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2010.04.007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.70159"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12206"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-4488(01)00266-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.22456\/1679-9216.112574"}],"container-title":["Veterinary 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