{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:31:51Z","timestamp":1786699911727,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Clinical Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Feline pulmonary Langerhans cell histiocytosis (FPLCH) is a rare histiocytic disorder in cats, usually diagnosed post\u2010mortem following natural death or euthanasia for severe respiratory distress. Antemortem diagnosis has been reported only once, achieved by cytologic examination of bronchoalveolar lavage fluid combined with immunocytochemistry, whereas fine\u2010needle aspiration (FNA) of lung nodules was previously reported as non\u2010diagnostic. Here we describe two cases of FPLCH in which cytology of ultrasound\u2010guided lung\u2010nodule FNA yielded diagnostic material, including from one cat with an atypical clinical presentation. Whereas case 1 presented with severe respiratory distress, case 2 had no respiratory signs. Both specimens were highly cellular and composed of atypical cells morphologically most consistent with histiocytes showing moderate atypia. A combination of postmortem gross, histopathologic, immunophenotypic, and ultrastructural findings confirmed the cytologic suspicion of FPLCH. To our knowledge, this is the first cytologic description of FPLCH in FNA samples from lung nodules and the first report of a confirmed case without respiratory signs.<\/jats:p>","DOI":"10.1111\/vcp.70141","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:47:56Z","timestamp":1786697276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fine\u2010Needle Aspirate Cytology of Feline Pulmonary Langerhans Cell Histiocytosis in Two Cats"],"prefix":"10.1111","author":[{"given":"Karuna","family":"Katariwala","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martim","family":"Matias","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine\u2013Lus\u00f3fona University\u2013Lisbon University Center  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Amores\u2010Fuster","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroteia","family":"Bota","sequence":"additional","affiliation":[{"name":"Anicura Restelo Veterinary Hospital  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Rocchigiani","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, Leahurst Campus University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0563-7737","authenticated-orcid":false,"given":"Carolina","family":"Naranjo","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar\u00e9 Pinto","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Vedis \u2013 Veterinary Expertise in Diagnosis  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-8649","authenticated-orcid":false,"given":"Martina","family":"Piviani","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19842384"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45\u20106\u2010816"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13304"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2022.07.010"},{"key":"e_1_2_8_6_1","first-page":"322","volume-title":"Tumors in Domestic Animals","author":"Moore P. F.","year":"2020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14071011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813510413"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985820953538"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1961.80"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01190\u20102019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u2010165X.2008.00005.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43\u20105\u2010646"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638719884950"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12152"}],"container-title":["Veterinary Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.70141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vcp.70141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vcp.70141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:47:57Z","timestamp":1786697277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vcp.70141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":14,"alternative-id":["10.1111\/vcp.70141"],"URL":"https:\/\/doi.org\/10.1111\/vcp.70141","archive":["Portico"],"relation":{},"ISSN":["0275-6382","1939-165X"],"issn-type":[{"value":"0275-6382","type":"print"},{"value":"1939-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"2025-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"vcp.70141"}}