{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:33:49Z","timestamp":1776926029684,"version":"3.51.2"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T00:00:00Z","timestamp":1369353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic progressive generalized alopecia in dairy cattle has been anecdotally discussed in veterinary forums.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe subclinical changes in an otherwise apparently healthy animal with chronic progressive generalized alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>One 10\u2010month\u2010old Jersey heifer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A heifer was presented for chronic progressive alopecia. The skin was hyperpigmented and very thin (2.4\u00a0\u00b1\u00a00.0\u00a0mm, compared with 8.1\u00a0\u00b1\u00a00.3\u00a0mm measured in four contemporaneous Jersey heifers). Histopathological examination of the skin revealed severe epidermal hyperplasia, orthokeratotic hyperkeratosis and diffuse follicular atrophy. Clinicopathological changes included hypocalcaemia that did not respond to calcium therapy. Serum parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) was not detected, compared with 1.38\u00a0\u00b1\u00a00.78 pmol\/L in four contemporaneous Jersey heifers. A diagnosis of hypoparathyroidism was made based on hypocalcaemia and low <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> in the presence of normal magnesium levels. The heifer was otherwise healthy and was allowed to continue normal life. A spontaneous abortion occurred at 5.5\u00a0months of pregnancy and this was likely due to the presence of twin fetuses. Despite targeted therapy of the ensuing retained placenta, the heifer declined in health and had to be euthanized. From the time of diagnosis with hypoparathyroidism until euthanasia (29\u00a0months of age), blood levels of calcium, phosphorus and <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> were regularly monitored. Calcium and phosphorus levels varied widely. Serum PTH was consistently undetectable. At postmortem examination, the parathyroid glands could not be located.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>To our knowledge, this is the first report of naturally occurring hypoparathyroidism in cattle and with a clinical presentation of alopecia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12036","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T11:31:35Z","timestamp":1369395095000},"page":"470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progressive alopecia associated with hypoparathyroidism in a <scp>J<\/scp>ersey heifer"],"prefix":"10.1111","volume":"24","author":[{"given":"Aurora","family":"Villarroel","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Oregon State University 221 Magruder Hall Corvallis OR 97331 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime L.","family":"Hustace","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Oregon State University 221 Magruder Hall Corvallis OR 97331 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Piripi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Oregon State University 106 Dryden Hall Corvallis OR 97331 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,24]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Large Animal Dermatology","author":"Scott DW","year":"1988"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.483"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0310609"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02686.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(64)88677-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(57)94573-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(66)88075-X"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(57)94572-1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb00496.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1999.tb12119.x"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:13:25Z","timestamp":1696151605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,24]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/vde.12036"],"URL":"https:\/\/doi.org\/10.1111\/vde.12036","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,24]]},"assertion":[{"value":"2013-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}