{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:48Z","timestamp":1787016048041,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T00:00:00Z","timestamp":1370390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Seborrhoeic keratoses (\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      s) are common benign epidermal neoplasms in humans and are rarely diagnosed in the dog. These circumscribed, raised, variably pigmented plaques arise in middle aged to older humans, with a focal or multicentric distribution; although common, the underlying cause of these lesions is not known. Although less common in the dog, the lesions are similar and have features that overlap with papillomavirus\u2010associated pigmented viral plaques.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Seborrhoeic keratoses in the dog are negative for canine papillomavirus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>\n                      Eleven cases of\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      from a 12\u00a0year period were reviewed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective study of the histopathological findings and case histories. Complete clinical records following collection of the skin biopsy were available in five of 11 cases. Immunohistochemistry was performed for all cases;\n                      <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                      analysis was carried out for papillomavirus in six cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histologically,\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      s had an exophytic to mildly endophytic epidermal proliferation, creating a papillomatous to acanthotic, hyperkeratotic, frequently pigmented plaque. There was an absence of hypergranulosis or viral cytopathic effect;\n                      <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                      s for canine papillomavirus within the formalin\u2010fixed paraffin\u2010embedded skin biopsies were negative. No breed, sex or site predilection was recognized. The mean age at biopsy of the lesions was 8.8\u00a0years (range 5\u201314\u00a0years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>\n                      Histopathological features and negative papillomavirus status distinguish\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      as an important differential diagnosis for pigmented viral plaques in dogs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.12039","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T08:04:41Z","timestamp":1370419481000},"page":"432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopathological findings of canine seborrhoeic keratosis with comparison to pigmented viral plaques"],"prefix":"10.1111","volume":"24","author":[{"given":"Charles W.","family":"Bradley","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Anatomic Pathology University of Pennsylvania School of Veterinary Medicine 3900 Delancey Street MJR VHUP 4037 Philadelphia PA 19104\u20106051 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Luff","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology University of California, Davis School of Veterinary Medicine One Shields Avenue 4206 VM3A Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Mauldin","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Anatomic Pathology University of Pennsylvania School of Veterinary Medicine 3900 Delancey Street MJR VHUP 4037 Philadelphia PA 19104\u20106051 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06788.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12246.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.18591952.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of The Dog and Cat; 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