{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:14:36Z","timestamp":1788423276465,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T00:00:00Z","timestamp":1370649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intradermal tests are used to identify allergens for avoidance and immunotherapy in atopic dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To evaluate cross\u2010reaction or co\u2010sensitization among 53 intradermal test allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Six hundred and fifty\u2010one client\u2010owned dogs with atopic dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intradermal tests were performed with 53 house dust\/storage mite, epidermal, insect, tree, weed and grass pollen and mould allergens. <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>airwise comparisons were used to calculate the odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s), 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) and statistical significance for the results of each allergen pair, with significance at <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0006 (Holm\u2013Bonferroni correction to reduce the false\u2010detection rate).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apart from cotton, cockroach, red clover, grain smut and <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>enicillium<\/jats:italic>, the results for the allergens within each group were statistically associated [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s from 4.7 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.5\u20138.9) to 1229.4 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 166.5\u20131795.1); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005 to <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001]. Excluding red clover and cotton, 94% of results between tree, weed and grass pollens were also statistically associated [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s from 8.3 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.6\u201324.7) to 117 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 29.1\u2013341); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005 to <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001]. In contrast, few allergens from unrelated groups were statistically associated [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s from 0.12 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.03\u20131.1) to 27.7 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.2\u201393); <jats:italic>P<\/jats:italic>\u00a0=\u00a01.0 to <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001]. The mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) of the log e transformed <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s for the related and statistically associated allergens [5.3 (1.3)] was significantly greater than those for related but nonstatistically associated [1.7 (1.6)] or unrelated allergens [1.4 (1.4); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>This suggests that there is cross\u2010reaction or co\u2010sensitization between related allergens. This could have implications for allergen selection in testing and immunotherapy, but further studies are required to differentiate cross\u2010reaction from co\u2010sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12044","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T10:08:45Z","timestamp":1370686125000},"page":"422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cross\u2010reaction and co\u2010sensitization among related and unrelated allergens in canine intradermal tests"],"prefix":"10.1111","volume":"24","author":[{"given":"Laura","family":"Buckley","sequence":"first","affiliation":[{"name":"The University of Liverpool School of Veterinary Science Leahurst Campus Chester High Road Neston Cheshire CH64 7TE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Schmidt","sequence":"additional","affiliation":[{"name":"The University 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