{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:43:42Z","timestamp":1789098222408,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent flank alopecia is a clinically well\u2010described skin disorder in dogs. The pathomechanism of the disease is difficult to study because it undergoes spontaneous regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To study the behaviour of xenografts in mice in order to assess the feasibility of a reproducible experimental model and to investigate local or systemic causes of canine recurrent flank alopecia (c<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsies were taken from lesional and nonlesional skin of two client\u2010owned dogs with c<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> and grafted onto five athymic mice from a research facility. The lesional skin and xenografted skin were evaluated histologically on day\u00a00 and day\u00a030, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transplanted lesional and nonlesional canine skin regrew hair within 30\u00a0days, while the donor dogs were still alopecic in the lesional areas on day\u00a030 after the skin biopsy procedure. Graft rejection was evidenced histologically in two xenografted athymic mice. Lesional hyperpigmentation disappeared in the athymic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>This study showed that hair follicles from dogs with c<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> quickly regenerated and regrew hair once grafted onto the mice. Our data indicate that the pathogenesis of c<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> is likely to be mediated by systemic rather than local factors. While this xenograft approach might not be of much value for the study of c<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content>, it has potential value for the study of other causes of canine alopecia due to systemic factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12059","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T14:26:38Z","timestamp":1374243998000},"page":"507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Study of the behaviour of lesional and nonlesional skin of canine recurrent flank alopecia transplanted to athymic nude mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Sophie I.","family":"Vandenabeele","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Biology of Small Animals Ghent University Salisburylaan 133 9820 Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"DeCock","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Services\/Medvet Emiel Vloorsstraat 9 2020 Antwerpen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Ham","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Biology of Small Animals Ghent University Salisburylaan 133 9820 Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Meyer","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Biochemistry Ghent University Salisburylaan 133 9820 Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Daminet","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Biology of Small Animals Ghent University Salisburylaan 133 9820 Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"155","volume-title":"Hair Loss Disorders in Domestic Animals","author":"Paradis M","year":"2009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_6_4_1","first-page":"83","volume-title":"BSAVA Manual of Small Animal Dermatology","author":"Paradis M","year":"2003"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Mini Review. Melatonin and the hair follicle","volume":"24","author":"Fisher TW","year":"2007","journal-title":"J Pineal Res"},{"key":"e_1_2_6_6_1","first-page":"300","article-title":"Overview. Primer for non\u2010immunologists on immune\u2010deficient mice and their applications in research","volume":"51","author":"Croy BA","year":"2001","journal-title":"Comp Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.95"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246750"},{"key":"e_1_2_6_9_1","first-page":"252","article-title":"The influence of the hair\u2010follicle cycle on skin allografts in the congenitally athymic \u201cnude\u201d mouse","volume":"62","author":"Ramselaar CG","year":"1981","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_6_10_1","first-page":"5","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12471822"},{"key":"e_1_2_6_12_1","first-page":"4448","article-title":"Guinea pig cutaneous nevi transplanted to athymic nude mice: a potential model for benign and malignant melanocytic lesions","volume":"43","author":"Stubbs RH","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.2.488"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:07:03Z","timestamp":1696151223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,19]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/vde.12059"],"URL":"https:\/\/doi.org\/10.1111\/vde.12059","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,19]]},"assertion":[{"value":"2013-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}