{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:00:46Z","timestamp":1773147646081,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Within the context of an increased epidemiological pressure caused by canine distemper virus (<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>) in Switzerland together with a potential re\u2010emergence of endemic pathogens such as orthopoxviruses (<jats:styled-content style=\"fixed-case\">OPXV<\/jats:styled-content>), dual infections are possible among susceptible species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a case of concurrent<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">OPXV<\/jats:styled-content>infection in a cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<\/jats:title><jats:p>A 5\u2010year\u2010old, neutered male cat was presented with erythema, crusts and ulcerations around the left eye. High\u2010grade pruritus and a severe conjunctivitis were also present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Formalin\u2010fixed skin biopsy samples were obtained from lesional skin. Histopathology,<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>immunohistochemistry and<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">OPXV RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathological examination showed severe epidermal necrosis extending to the follicular walls and a dermal infiltration, predominantly eosinophilic. Intranuclear and intracytoplasmic eosinophilic inclusion bodies were visible in the wall of affected hair follicles, with occasional formation of syncytia. The<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>revealed the contextual presence of both<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">OPXV<\/jats:styled-content>. Scattered cells stained positive for<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and discussion<\/jats:title><jats:p>Dual infections with<jats:styled-content style=\"fixed-case\">CDV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">OPXV<\/jats:styled-content>, although rare, may occur and represent additional differential diagnoses for ulcerative skin lesions in cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12063","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T14:27:00Z","timestamp":1374244020000},"page":"543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cutaneous lesions associated with dual infection caused by canine distemper virus and orthopoxvirus in a domestic cat"],"prefix":"10.1111","volume":"24","author":[{"given":"Dominique J.","family":"Wiener","sequence":"first","affiliation":[{"name":"Institute of Animal Pathology Vetsuisse Faculty University of Bern L\u00e4nggasstrasse 122 PO Box 8466 3001 Bern Switzerland"},{"name":"DermFocus Vetsuisse Faculty University of Bern L\u00e4nggasstrasse 122 PO Box 8466 3001 Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika M.","family":"Welle","sequence":"additional","affiliation":[{"name":"Institute of Animal Pathology Vetsuisse Faculty University of Bern L\u00e4nggasstrasse 122 PO Box 8466 3001 Bern Switzerland"},{"name":"DermFocus Vetsuisse Faculty University of Bern L\u00e4nggasstrasse 122 PO Box 8466 3001 Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco C.","family":"Origgi","sequence":"additional","affiliation":[{"name":"Institute of Animal Pathology Vetsuisse Faculty University of Bern L\u00e4nggasstrasse 122 PO Box 8466 3001 Bern Switzerland"},{"name":"Centre for Fish and Wildlife 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