{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:54:21Z","timestamp":1696269261432},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T00:00:00Z","timestamp":1376006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Calciphylaxis is a rare cutaneous disorder, characterized by vascular calcification and progressive skin necrosis, not yet described in cats. It is scarcely reported in animals, mostly due to iatrogenic or uraemic disturbances of the calcium\u2013phosphate balance. In human patients, it is most commonly seen with end\u2010stage renal disease, but several nonuraemic disorders, including inherited dysfunctions of tissue calcification inhibitors, have also been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To describe a case of nonuraemic calciphylaxis in a cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>A 10\u2010week\u2010old male domestic short hair kitten was presented with hyperacute skin lesions. Initial dermatological signs were characterized by sharp demarcated erosions and ulcerations on the face, including the nasal planum and lips. Cutaneous lesions rapidly progressed into thick crusts with ulcerations, involving parts of the face and pinna as well as abdominal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Complete blood count, serum chemistry profile, urinalysis, parathyroid hormone measurement and histopathological examination of skin biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathology from newly developed abdominal skin lesions revealed severe epidermal necrosis and calcification, multifocal pannicular calcification and calcified subcutaneous vessels, supporting a diagnosis of calciphylaxis. Treatment consisted of systemic and topical antimicrobials, analgesics, pentoxifylline, Lantharenol<jats:sup>\u00ae<\/jats:sup>, sodium thiosulfate and vitamin\u00a0K. After initiation of therapy, no further progression was noticed; all medications could be discontinued eventually, and no relapse was seen in the following 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Calciphylaxis should be considered as a differential diagnosis for ulcerative cutaneous disorders in young cats. More information on this disease is needed to elucidate the pathomechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12064","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T12:03:37Z","timestamp":1376049817000},"page":"547","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nonuraemic nonfatal idiopathic calciphylaxis in a kitten"],"prefix":"10.1111","volume":"24","author":[{"given":"Nina","family":"Thom","sequence":"first","affiliation":[{"name":"Small Animal Clinic Veterinary Faculty Justus\u2010Liebig\u2010University Frankfurter Stra\u00dfe 126 35392 Giessen Germany"},{"name":"Tierklinik Hofheim Im Langgewann 9 65719 Hofheim am Taunus Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Er","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Veterinary Faculty Justus\u2010Liebig\u2010University Frankfurter Stra\u00dfe 126 35392 Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Reinacher","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Veterinary Faculty Justus\u2010Liebig\u2010University Frankfurter Stra\u00dfe 96 35392 Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.5301\/JN.2011.6366"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332221"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00530108"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00418.x"},{"key":"e_1_2_4_6_1","unstructured":"NunleyJR. 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