{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:53:28Z","timestamp":1771462408284,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T00:00:00Z","timestamp":1376006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pyoderma gangrenosum (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) is a rare disease, which, to the best of the authors' knowledge, has been the subject of only one case report in the peer\u2010reviewed veterinary literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To describe the history, clinical signs, diagnostic findings and treatment outcome in two cases of canine <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Two client\u2010owned dogs presented to a private veterinary referral practice between 2008 and 2010 who received a diagnosis of PG by specialist veterinary dermatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were analysed to retrieve relevant information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both dogs were treated with prednisolone; this was combined with ciclosporin in case\u00a01 and azathioprine in case\u00a02. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ase 2 had a more complete response of lesions to treatment and a longer survival time after diagnosis (763\u00a0days) than case\u00a01 (81\u00a0days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Pyoderma gangrenosum is a rare disease distinguished by rapid progression of painful, necrolytic, cutaneous ulcers with irregular, violaceous undermined borders. Azathioprine with glucocorticoids may lead to a better outcome than ciclosporin and glucocorticoids (currently the first\u2010line treatment in humans and the only reported treatment in dogs).<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12065","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T12:03:36Z","timestamp":1376049816000},"page":"552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Canine pyoderma gangrenosum: a case series of two dogs"],"prefix":"10.1111","volume":"24","author":[{"given":"Deborah L.","family":"Simpson","sequence":"first","affiliation":[{"name":"Animal Dermatology Solutions 26 Fowler Street Box Hill South Victoria 3128 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory G.","family":"Burton","sequence":"additional","affiliation":[{"name":"Animal Skin, Ear and Allergy Service 70 Blackburn Road, Glen Waverley Melbourne Victoria 3150 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia E.","family":"Hambrook","sequence":"additional","affiliation":[{"name":"Advanced Vetcare 26 Robertson Street, Kensington Melbourne Victoria 3031 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00209.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat","author":"Gross TL","year":"2005"},{"key":"e_1_2_6_4_1","first-page":"709","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02128.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(99)00119-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(99)00129-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00316.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00414_55.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03199.x"},{"key":"e_1_2_6_11_1","first-page":"173","article-title":"Pyoderma gangrenosum: a review of 86 patients","volume":"55","author":"Powell FC","year":"1985","journal-title":"Q J Med"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90428-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20559"},{"key":"e_1_2_6_14_1","first-page":"1281","volume-title":"Plumb's Veterinary Drug Handbook","author":"Plumb DC","year":"2011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.20022083.x"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12065","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:07:41Z","timestamp":1696151261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,9]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/vde.12065"],"URL":"https:\/\/doi.org\/10.1111\/vde.12065","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,9]]},"assertion":[{"value":"2013-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}