{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:01:36Z","timestamp":1784124096767,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T00:00:00Z","timestamp":1377216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dermatophytosis is an important contagious and infectious skin disease in an animal shelter. Itraconazole is the commonly used systemic antifungal drug, but it is expensive in some countries and, at times, difficult to obtain. Terbinafine is a fungicidal allylamine with documented<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>efficacy against<jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>icrosporum canis<\/jats:italic>in pet cats and in cats with experimental infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To describe the use of oral terbinafine for the treatment of<jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0canis<\/jats:italic>dermatophytosis in shelter cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The response to treatment of 85 shelter cats with naturally occurring<jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0canis<\/jats:italic>dermatophytosis was monitored by examination, weekly toothbrush fungal cultures and the number of colony\u2010forming units on fungal culture plates. Cats were treated with either 14 (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) or 21\u00a0days (<jats:italic>n<\/jats:italic>\u00a0=\u00a064) of terbinafine per os (p.o.) along with concurrent twice weekly lime sulphur rinses and daily environmental disinfection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cats treated with 14\u00a0days of terbinafine p.o. showed an initial response to therapy but by week\u00a06 had relapsed and required rescue therapy with a course of itraconazole (10\u00a0mg\/kg p.o.) to obtain a cure. Cats treated with 21\u00a0days of terbinafine p.o. showed a response to treatment similar to published reports using itraconazole p.o. for 21\u00a0days. The mean and median number of days to mycological cure was 22.70 (range 13\u201339). Terbinafine was well tolerated. None of the cats developed oral lesions postgrooming of lime sulphur rinses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Where itraconazole is not available, substitution with terbinafine in established protocols may allow shelters to treat cats that otherwise would go untreated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12069","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T14:16:56Z","timestamp":1377267416000},"page":"618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Treatment of shelter cats with oral terbinafine and concurrent lime sulphur rinses"],"prefix":"10.1111","volume":"24","author":[{"given":"Karen","family":"Moriello","sequence":"first","affiliation":[{"name":"Department of Medical Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison 2015 Linden Drive West Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Coyner","sequence":"additional","affiliation":[{"name":"Dermatology Clinic for Animals 5231 West Charleston Boulevard Las Vegas NV 89146 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Trimmer","sequence":"additional","affiliation":[{"name":"Animal Allergy and Dermatology Specialists 6032 Durango, Suite 100 Las Vegas NV 89133 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Newbury","sequence":"additional","affiliation":[{"name":"Koret Shelter Medicine Program UC Davis School of Veterinary Medicine One Shields Avenue Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcie","family":"Kunder","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison 2015 Linden Drive West Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00618.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00789.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00914.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2754\/avb200675040541"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(01)00412-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-612X(99)90008-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00603.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2460\/javma.1995.207.04.0439","article-title":"Efficacy of griseofulvin and itraconazole in the treatment of experimentally induced dermatophytosis in cats","volume":"207","author":"Moriello KA","year":"1995","journal-title":"J Am Vet Med Assoc"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T02:22:05Z","timestamp":1715912525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,23]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/vde.12069"],"URL":"https:\/\/doi.org\/10.1111\/vde.12069","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,23]]},"assertion":[{"value":"2013-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}