{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:44:45Z","timestamp":1790257485522,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Histoplasma capsulatum<\/jats:italic>has a worldwide distribution, but reports in Europe remain rare. We present the second report of histoplasmosis in a cat in Europe and, to the best of our knowledge, the first case of feline histoplasmosis infection apparently limited to the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 6\u2010year\u2010old male castrated outdoor cat was presented to the dermatology service with a history of skin lesions evolving over 1\u00a0month and consisting of multiple papules and nodules on the head and neck. General examination was unremarkable. Cytological examination of the ulcerated nodules revealed a pyogranulomatous infiltrate, with numerous macrophages containing oval yeast\u2010like cells, 2\u20135\u00a0\u03bcm in size, with a central, lightly basophilic core surrounded by a clear halo. A tentative diagnosis of fungal infection was made, and skin biopsy specimens were taken. Histological examination confirmed the cytology findings, and Grocott staining showed numerous organisms suggestive of<jats:italic>Histoplasma<\/jats:italic>within macrophages. Thoracic radiographs, abdominal ultrasound and routine laboratory testing were unremarkable. Fungal culture of a nodule was negative.<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>of total<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>extracted from the infected tissue and subsequent sequencing confirmed the diagnosis of<jats:italic>H.\u00a0capsulatum<\/jats:italic>var.<jats:italic>capsulatum<\/jats:italic>. Surgical excision of the other nodules was performed, and the cat was treated with oral itraconazole 5\u00a0mg\/kg once daily; 12\u00a0weeks after initial consultation, no lesions were visible. No recurrence was observed during an 8\u00a0month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Histoplasmosis should be included in the differential diagnosis of nodular diseases of cats worldwide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12077","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:59:24Z","timestamp":1381543164000},"page":"635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A case in Europe of feline histoplasmosis apparently limited to the skin"],"prefix":"10.1111","volume":"24","author":[{"given":"Nina M.","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Dermatology Vetsuisse Faculty University of Zurich Winterthurerstrasse 260 8057 Zurich 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