{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:30Z","timestamp":1787016030943,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"\n Background<\/jats:title>\n \n Multicentric squamous cell carcinoma\n in situ<\/jats:italic>\n (\n MSCCIS<\/jats:styled-content>\n ) is an uncommon cutaneous disease of middle\u2010aged to older cats, with some cases being linked to papillomavirus infection. The disease course is usually benign. Initial eruption of multifocal, pigmented, hyperkeratotic plaques is typical, with gradual progression to thickly crusted ulcerative lesions.\n <\/jats:p>\n <\/jats:sec>\n \n Animal<\/jats:title>\n \n A 5\u2010year\u2010old male neutered\n D<\/jats:styled-content>\n evon rex cat in apparent good health was initially presented with a 16\u00a0month history of over 40 nonpruritic dorsally distributed hyperpigmented patches. Lesions progressed gradually over 2\u00a0years to larger, more pigmented, crusted plaques and ulcerated nodules. At 7\u00a0years of age the cat developed neurological signs and systemic illness and was euthanized.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n Initial skin histopathology revealed discrete regions of epidermal and follicular epithelial hyperplasia, with moderate numbers of apoptotic keratinocytes, and mild focal epithelial dysplasia. A diagnosis of erythema multiforme was considered; feline herpesvirus\u20101 immunohistochemistry was negative. Repeat histopathology 22\u00a0months after initial presentation confirmed\n MSCCIS<\/jats:styled-content>\n with foci of invasive squamous cell carcinoma (\n SCC<\/jats:styled-content>\n ). Postmortem examination 1\u00a0month later revealed\n SCC<\/jats:styled-content>\n within the thoracic wall, lungs and vessels of the thoracic spinal cord and heart base, presumed to be metastases from skin lesions. Fluorescent\n in situ<\/jats:italic>\n hybridization of initial and later histopathology samples was positive for\n \n F<\/jats:styled-content>\n elis domesticus\n <\/jats:italic>\n papillomavirus type\u00a02. Immunoreactivity of p16 was prominent within early and late cutaneous lesions and internal\n SCC<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This case represents an unusual presentation of papillomavirus\u2010associated\n MSCCIS<\/jats:styled-content>\n with extensive lesions, atypical initial histopathology and progression to\n SCC<\/jats:styled-content>\n with distant metastases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.12080","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T07:21:39Z","timestamp":1381735299000},"page":"642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Papillomavirus\u2010associated multicentric squamous cell carcinoma\n in situ<\/i>\n in a cat: an unusually extensive and progressive case with subsequent metastasis"],"prefix":"10.1111","volume":"24","author":[{"given":"Philippa A.","family":"Ravens","sequence":"first","affiliation":[{"name":"Small Animal Specialist Hospital Level 1, 1 Richardson Place North Ryde NSW 2113 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Vogelnest","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital Level 1, 1 Richardson Place North Ryde NSW 2113 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia J.","family":"Tong","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Services Faculty of Veterinary Science University of Sydney Camperdown NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Demos","sequence":"additional","affiliation":[{"name":"School of Veterinary and Biomedical Sciences Murdoch University South Street Murdoch WA 6150 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Bennett","sequence":"additional","affiliation":[{"name":"School of Veterinary and Biomedical Sciences Murdoch University South Street Murdoch WA 6150 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"783","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00685.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00958.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat. 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