{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:21:58Z","timestamp":1784071318144,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prednisone doses of up to 8\u00a0mg\/kg\/day have been used to treat feline pemphigus foliaceus (<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>). Oral prednisolone has more favourable pharmacokinetics in cats than prednisone; therefore, lower doses of prednisolone may be effective in treating feline <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To assess the dose of prednisolone required to induce and maintain remission of <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> in cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirty\u2010seven client\u2010owned cats with a diagnosis of <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> treated with prednisolone monotherapy for induction of remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of records of a veterinary dermatology referral practice between the years of 1995 and 2013 was carried out. History, clinical signs, cytological and\/or histopathological findings, lack of response to antimicrobials, absence of fungal hyphae on periodic acid <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chiff staining and\/or negative fungal culture and positive response to immunosuppressive therapy were used to confirm the diagnosis. Cats were included in the study if prednisolone was used as the monotherapy induction protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete remission was achieved within 8\u00a0weeks in 97% of cats with a median induction dose of 2\u00a0mg\/kg prednisolone daily. In cats requiring ongoing treatment, 67% were maintained in remission with prednisolone monotherapy. The median maintenance dose was 1.2\u00a0mg\/kg\/week. In 14% of cats, medication was eventually discontinued.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Daily prednisolone at 2\u00a0mg\/kg is an effective dose for inducing remission of <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> in cats. Adverse effects were uncommon with this dose. In a small population, permanent remission may be induced. Secondary bacterial overgrowth and exudate in claw folds resolved in all cases with immunosuppressive therapy; therefore, antimicrobial therapy may be unnecessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12081","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:23:44Z","timestamp":1381544624000},"page":"598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Use of prednisolone as monotherapy in the treatment of feline pemphigus foliaceus: a retrospective study of 37 cats"],"prefix":"10.1111","volume":"24","author":[{"given":"Deborah L.","family":"Simpson","sequence":"first","affiliation":[{"name":"Animal Dermatology Solutions 26 Fowler Street Box Hill South Melbourne Victoria 3128 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory G.","family":"Burton","sequence":"additional","affiliation":[{"name":"Animal Skin, Ear and Allergy Service 70 Blackburn Road Glen Waverley Melbourne Victoria 3150 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00540.x"},{"key":"e_1_2_6_3_1","first-page":"573","volume-title":"Current Veterinary Therapy XII: Small Animal Practice","author":"Scott DW","year":"1995"},{"key":"e_1_2_6_4_1","first-page":"2783","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Werth VP","year":"1999"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00360.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01069.x"},{"key":"e_1_2_6_7_1","first-page":"424","article-title":"Immune\u2010mediated dermatoses in domestic animals: ten years after \u2013 Part I","volume":"9","author":"Scott DW","year":"1987","journal-title":"Compend Cont Educ Pract Vet"},{"key":"e_1_2_6_8_1","first-page":"432","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_6_9_1","first-page":"433","article-title":"Pemphigus diseases in the feline: seven case reports and discussion","volume":"18","author":"Manning TO","year":"1982","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2003.00347.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00717.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(92)90030-6"},{"key":"e_1_2_6_13_1","first-page":"152","volume-title":"Advances in Veterinary Dermatology","author":"Graham\u2010Mize CA","year":"2005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.02.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.24.777"},{"key":"e_1_2_6_16_1","first-page":"104","article-title":"Some effects of short\u2010term methylprednisolone therapy in normal cats","volume":"69","author":"Scott DW","year":"1979","journal-title":"Cornell Vet"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.11.1486"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111506"},{"key":"e_1_2_6_19_1","first-page":"140","article-title":"Risk factors in pemphigus","volume":"45","author":"Dermici GT","year":"2011","journal-title":"Turkderm"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:43:09Z","timestamp":1695976989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/vde.12081"],"URL":"https:\/\/doi.org\/10.1111\/vde.12081","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,9]]},"assertion":[{"value":"2013-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}