{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:27:53Z","timestamp":1761863273408},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The conversion of arachidonic acid into prostaglandin is catalysed by the cyclo\u2010oxygenases (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102). Several studies indicate that <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 is overexpressed in actinic keratosis in humans and dogs. Firocoxib is a <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102\u2010selective inhibitor that blocks the biochemical activity of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To evaluate the efficacy of firocoxib (5\u00a0mg\/kg orally once daily) for the treatment of dogs with solar dermatitis\/actinic keratosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Firocoxib 5\u00a0mg\/kg was given orally once daily for 180\u00a0days to five dogs with clinical signs and histopathological lesions consistent with solar dermatitis\/actinic keratosis. On days\u00a00, 50 and 180, the severity of erythema, skin shine, induration and the number of comedones were evaluated by a clinical scoring system. On the same days, samples were collected for histopathology from \u2018target lesions\u2019 and <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expression was evaluated by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical follow\u2010up showed that four of five dogs improved with the treatment; improvement in terms of histological findings was correlated with the regularization of the epidermal proliferation rather than the recovery of dermal changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>A role for <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 might thus be hypothesized in the pathogenesis of canine solar dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12082","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T16:26:16Z","timestamp":1381854376000},"page":"606","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical outcome and cyclo\u2010oxygenase\u20102 expression in five dogs with solar dermatitis\/actinic keratosis treated with firocoxib"],"prefix":"10.1111","volume":"24","author":[{"given":"Francesco","family":"Albanese","sequence":"first","affiliation":[{"name":"Private Practice Clinica San Clemente Via Pietro Benvenuti 7 52100 Arezzo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Abramo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa Viale delle Piagge 2 56124 Pisa 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