{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T22:08:30Z","timestamp":1774649310206,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Paraneoplastic pemphigus (<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>) is a rare and severe autoimmune blistering skin disease of humans. It is associated mainly with haematopoietic neoplasia and a unique autoantibody profile. At this time and in animals,<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>has only been reported in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report clinical, histological and immunological findings in a cat with suspected thymoma\u2010associated<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<\/jats:title><jats:p>An 8\u2010year\u2010old female spayed<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>imalayan cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cat presented with a thoracic mass diagnosed as a lymphocytic thymoma. Two weeks postremoval, the cat developed myasthenia gravis, which was controlled with prednisolone and pyridostigmine. The myasthenia gravis resolved, but the cat developed severe cutaneous erosions and ulcers primarily affecting the caudal ventral abdomen and perineum, but also the ventral chest, axillae and medial pinnae. Histopathological analysis revealed changes consistent with pemphigus vulgaris and erythema multiforme, a combination of lesions highly suggestive of<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. Direct immunofluorescence revealed intercellular epidermal IgG deposition in the lower epidermis, especially in areas of suprabasal clefts. Indirect immunofluorescence revealed antikeratinocyte IgG to basal keratinocytes and bladder epithelial cells. Immunological results supported a diagnosis of<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. Skin lesions were treated with prednisolone and chlorambucil and, after clinical remission was obtained, the drugs were tapered and eventually discontinued without further recurrence of skin lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>In this cat, clinical, microscopic and immunological findings were consistent with a diagnosis of<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>, with thymoma being the suspected cause.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12086","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T12:45:00Z","timestamp":1382964300000},"page":"646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Putative paraneoplastic pemphigus and myasthenia gravis in a cat with a lymphocytic thymoma"],"prefix":"10.1111","volume":"24","author":[{"given":"Peter B.","family":"Hill","sequence":"first","affiliation":[{"name":"Companion Animal Health Centre School of Animal and Veterinary Sciences University of Adelaide Roseworthy SA 5371 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Brain","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital Level 1 1 Richardson Place North Ryde Sydney NSW 2113 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Collins","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital Level 1 1 Richardson Place North Ryde Sydney NSW 2113 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Fearnside","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital Level 1 1 Richardson Place North Ryde Sydney NSW 2113 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Olivry","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Center for Comparative Medicine and Translational Research North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00059-1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00322.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-0-387-68858-9","volume-title":"Deadly Dermatologic Diseases","author":"Morgan MB","year":"2007"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.1998.00095.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-1-88"},{"key":"e_1_2_4_7_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2460\/javma.1975.166.06.575","article-title":"A mucocutaneous disease in the dog, resembling pemphigus vulgaris in man","volume":"166","author":"Stannard AA","year":"1975","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80173-9"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.03.018"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107750"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00192-9"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00280.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70147-7"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0901-y"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09845.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012250"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00806.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-4-429"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90066-7"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2011.00636.x"},{"key":"e_1_2_4_21_1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2460\/javma.1994.205.07.1007","article-title":"Thymoma in dogs: 23 cases (1980\u20131991)","volume":"205","author":"Atwater SW","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2003.tb12883.x"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2008.00290.x"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T18:33:13Z","timestamp":1746037993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,28]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/vde.12086"],"URL":"https:\/\/doi.org\/10.1111\/vde.12086","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,28]]},"assertion":[{"value":"2013-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}