{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:36:44Z","timestamp":1765355804896,"version":"3.40.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Feline demodicosis due to<jats:italic>Demodex cati<\/jats:italic>is a rare skin disease often associated with concurrent disease and generalized immunosuppression. Local immunosuppression due to the application of topical immunomodulatory drugs, such as glucocorticoids and tacrolimus, or by tumour cells has been suggested as a potential trigger for development of localized demodicosis in humans and animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal was to describe two cats with asthma that developed localized demodicosis on the muzzle as a result of chronic therapy with a glucocorticoid administered via dispensing inhaler mask.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both cats, the muzzle area exposed to the fluticasone\u2010dispensing chamber exhibited patchy alopecia, mild erythema, crusting and scaling. Deep skin scraping revealed<jats:italic>D. cati<\/jats:italic>. Discontinuation or reduction of fluticasone and administration of milbemycin resulted in resolution of clinical signs within 2\u00a0months in both cats. A negative skin scrape was obtained after 7\u00a0months of milbemycin in one of the cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Demodicosis should be considered as a possible differential diagnosis in cats with primary alopecia or other skin lesions on the face exposed to inhalant glucocorticoids. Minimization of contact between the inhalant glucocorticoid and the skin can be achieved by wiping residual powder from the face and by keeping the mask tightly pressed to the skin to avoid contact with the surrounding area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12123","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T06:52:41Z","timestamp":1397199161000},"page":"222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Localized demodicosis due to<i>Demodex cati<\/i>on the muzzle of two cats treated with inhalant glucocorticoids"],"prefix":"10.1111","volume":"25","author":[{"given":"Petra","family":"Bizikova","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Center for Comparative Medicine and Translational Research College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 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