{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:37:53Z","timestamp":1757309873524},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Merck Animal Health, Summit, NJ, USA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Canine flea\u2010allergy dermatitis (<jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content>), a hypersensitivity response to antigenic material in the saliva of feeding fleas, occurs worldwide and remains a common presentation in companion animal veterinary practice despite widespread availability of effective systemic and topical flea\u2010control products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To evaluate the clinical response in dogs with <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> treated topically with indoxacarb, a novel oxadiazine insecticide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010five client\u2010owned dogs in Queensland, Australia diagnosed with pre\u2010existing <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> on the basis of clinical signs, flea\u2010antigen intradermal and serological tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open\u2010label, noncontrolled study, in which all dogs were treated with topical indoxacarb at 4\u00a0week intervals, three times over 12\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four dogs completed the study. Complete resolution of clinical signs of <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> was observed in 21 cases (87.5%), with nearly complete resolution or marked improvement in the remaining three cases. Mean clinical scores (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anine <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>topic <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatitis <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xtent and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>everity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex\u201003) were reduced by 93.3% at week\u00a012. Mean owner\u2010assessed pruritus scores were reduced by 88% by week\u00a012. Mean flea counts reduced by 98.7 and 100% in weeks\u00a08 and 12, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Topical indoxacarb treatment applied every 4\u00a0weeks for 12\u00a0weeks, without concomitant antipruritic or ectoparasiticide therapy, completely alleviated flea infestations in all dogs and associated clinical signs of <jats:styled-content style=\"fixed-case\">FAD<\/jats:styled-content> in a high proportion of this population of dogs in a challenging flea\u2010infestation environment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12132","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T07:17:05Z","timestamp":1399360625000},"page":"195","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An open, self\u2010controlled study on the efficacy of topical indoxacarb for eliminating fleas and clinical signs of flea\u2010allergy dermatitis in client\u2010owned dogs in Queensland, Australia"],"prefix":"10.1111","volume":"25","author":[{"given":"Petr","family":"Fisara","sequence":"first","affiliation":[{"name":"MSD Animal Health 26 Artisan Road Seven Hills NSW 2147 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger M.","family":"Sargent","sequence":"additional","affiliation":[{"name":"MSD Animal Health 26 Artisan Road Seven Hills NSW 2147 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Shipstone","sequence":"additional","affiliation":[{"name":"Dermatology for Animals 263 Appleby Road Stafford Heights Qld 4053 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"von Berky","sequence":"additional","affiliation":[{"name":"von Berky Veterinary Services 3 Hawthorne Street Woody Point Qld 4019 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"von Berky","sequence":"additional","affiliation":[{"name":"von Berky Veterinary Services 3 Hawthorne Street Woody Point Qld 4019 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-160422-6\/50047-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00204.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01092.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-126"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.42.1.451"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.03.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.03.035"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703853"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2005.10.004"},{"key":"e_1_2_6_11_1","unstructured":"GuerinoF QureshiT HairJet\u00a0al.Indoxacarb kills developing stages of fleas in the environment of treated cats. 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