{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:11:37Z","timestamp":1762161097893},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus foliaceus (<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>) is the most common IgG\u2010mediated autoimmune skin disease in dogs. Studies of human <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> have revealed the presence of other antigen\u2010specific autoantibody isotypes, thereby uncovering new avenues of investigation of the disease pathomechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The aim was to obtain information about the autoantibody isotype response in canine <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sera from 34 dogs with <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> were tested for the presence of antikeratinocyte, anti\u2010desmocollin\u20101 and anti\u2010desmoglein\u20101 IgA, IgE and IgM using indirect immunofluorescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using our indirect immunofluorescence technique, IgA, IgE and IgM autoreactivities were detected in six, one and zero of 34 sera from <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\u2010affected dogs, respectively. Two of the six IgA\u2010positive sera contained antikeratinocyte and anti\u2010desmocollin\u20101 IgA, while the four remaining sera tested positive either for antikeratinocyte IgA (two of six) or for anti\u2010desmocollin\u20101 IgA (two of six). A single serum contained anti\u2010desmocollin\u20101 IgE. None of the six sera from healthy dogs contained detectable IgA, IgE or IgM autoantibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Our findings suggest that sera from dogs with <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> rarely contain IgA or IgE autoantibodies at levels detectable by indirect immunofluorescence, while IgM autoreactivity appears not to be a feature of this disease. Considering these findings, it appears that canine <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> is aetiologically and immunologically similar to that of the classic human <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>, in which the IgG autoantibody response is also the predominant type.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12143","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T07:47:04Z","timestamp":1403855224000},"page":"471","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum autoantibody profiles of <scp>I<\/scp>g<scp>A<\/scp>,<scp> I<\/scp>g<scp>E<\/scp> and <scp>I<\/scp>g<scp>M<\/scp> in canine pemphigus foliaceus"],"prefix":"10.1111","volume":"25","author":[{"given":"Petra","family":"Bizikova","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Olivry","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa B.","family":"Mamo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley M.","family":"Dunston","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 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