{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:04:40Z","timestamp":1773417880488,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Exfoliative dermatitis has been described in cats as a paraneoplastic skin disease associated with thymoma. There are anecdotal reports of cases without thymoma, with various suspected aetiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To identify common features, underlying causes, response to therapy and outcome of nonthymoma\u2010associated exfoliative dermatitis in cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis was carried out of cases presented to dermatology referral centres or cases submitted for histopathological examination. Detailed historical and clinical data were obtained and evaluated statistically. Histopathology was reviewed in a blinded fashion by three dermatopathologists, and<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>for herpesvirus was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen cats fulfilled all inclusion criteria. There was no sex, age or breed predisposition. All cats presented with severe generalized (77%) or multifocal exfoliation (23%); 12 cats were severely depressed. In all cats, thymoma was excluded radiographically and feline leukaemia virus tests were negative. Additional imaging procedures in 14 cats and postmortem examination in two cats did not detect neoplasia. Histopathology revealed interface dermatitis, mural interface folliculitis and sebaceous adenitis indistinguishable from findings in thymoma\u2010associated cases.<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>for herpes<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>was negative. No aetiology was identified. Treatment in 12 cases consisted of immunosuppressive doses of corticosteroids and\/or ciclosporin; one responded to antibiotics, one to shampoo, two went into spontaneous remission, and two did not receive any therapy and were euthanized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Nonthymoma\u2010associated exfoliative dermatitis in cats is clinically and histopathologically indistinguishable from thymoma\u2010associated cases. Most cases benefit from immunosuppressive therapy; therefore, an immunopathological response to an undefined trigger is suspected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12169","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T05:15:50Z","timestamp":1415078150000},"page":"40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Nonthymoma\u2010associated exfoliative dermatitis in 18 cats"],"prefix":"10.1111","volume":"26","author":[{"given":"Monika","family":"Linek","sequence":"first","affiliation":[{"name":"Tieraerztliche Spezialisten Rodigallee 85 D\u201022043 Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"R\u00fcfenacht","sequence":"additional","affiliation":[{"name":"Dermavet Muhenstrasse 56 CH\u20105036 Oberentfelden 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