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The main feature of<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>in humans and animals is the formation of blisters and erosions in response to minor mechanical trauma.<\/jats:p><jats:p>Epidermolysis bullosa is caused by mutations in the genes that code for structural proteins of the cytoskeleton of the basal keratinocytes or of the basement membrane zone. Based on the ultrastructural levels of tissue separation,<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>is divided into the following three broad categories: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa. Human types of<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>are divided into several subtypes based on their ultrastructural changes and the mode of inheritance; subtypes are not fully established in animals. In humans, it is estimated that<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>affects one in 17,000 live births; the frequency of<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>in different animals species is not known.<\/jats:p><jats:p>In all animal species, except in buffalo with epidermolysis bullosa simplex, multifocal ulcers are observed on the gums, hard and soft palates, mucosa of the lips, cheek mucosa and dorsum of the tongue. Dystrophic or absent nails, a frequent sign seen in human patients with<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>, corresponds to the deformities and sloughing of the hooves in ungulates and to dystrophy or atrophy of the claws in dogs and cats.<\/jats:p><jats:p>This review covers aspects of the molecular biology, diagnosis, classification, clinical signs and pathology of<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>reported in animals.<\/jats:p>","DOI":"10.1111\/vde.12176","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T07:32:00Z","timestamp":1414654320000},"page":"3","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Epidermolysis bullosa in animals: a review"],"prefix":"10.1111","volume":"26","author":[{"given":"Gildenor X.","family":"Medeiros","sequence":"first","affiliation":[{"name":"Postgraduate Program in Veterinary Medicine Veterinary Hospital Federal University of Campina Grande Patos Para\u00edba CEP 58708\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Riet\u2010Correa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Veterinary Medicine Veterinary Hospital Federal University of Campina Grande Patos Para\u00edba CEP 58708\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.75"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00800.x"},{"key":"e_1_2_8_4_1","first-page":"127","article-title":"The biomolecular and ultrastructural basis of epidermolysis bullosa","volume":"14","author":"Solovan C","year":"2005","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200600584157"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.12.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.07.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(03)00045-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1974.34133"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.94.8.153"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.2460\/javma.1988.193.11.1420","article-title":"Hereditary junctional mechanobullous disease in a foal","volume":"193","author":"Frame SR","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1989.tb02173.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200311"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-5-576"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700731"},{"key":"e_1_2_8_17_1","first-page":"1139","article-title":"Genetic bases of canine junctional epidermolysis bullosa","volume":"113","author":"Spirito F","year":"1999","journal-title":"J Invest Dermatol"},{"key":"e_1_2_8_18_1","first-page":"532","article-title":"Characterization of a spontaneous animal model of recessive dystrophic epidermolysis bullosa: implications for somatic gene therapy","volume":"115","author":"Gache Y","year":"2000","journal-title":"J Invest Dermatol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01852.x"},{"key":"e_1_2_8_20_1","unstructured":"BairdJD MillonLV DileanisSet\u00a0al.Junctional epidermolysis bullosa in Belgian draft horses. 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