{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T13:08:57Z","timestamp":1713186537103},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The bone marrow may be involved in human atopic diseases, as shown by the release of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cells into the peripheral blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The aim was to determine the numbers of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cells in atopic dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>The following three groups of dogs were studied: 27 dogs with nonfood\u2010induced atopic dermatitis (<jats:styled-content style=\"fixed-case\">NFICAD<\/jats:styled-content>); 16 dogs with nonallergic inflammatory diseases; and 13 healthy control dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs with <jats:styled-content style=\"fixed-case\">NFICAD<\/jats:styled-content> were selected after fulfilment of Favrot's criteria and exclusion of other pruritic dermatoses, including flea infestation and adverse reaction to foods. The Canine Atopic Dermatitis Extent and Severity Index (<jats:styled-content style=\"fixed-case\">CADESI<\/jats:styled-content>)\u201003 and a Visual Analog Scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) score for pruritus were used to quantify clinical signs. A phycoerythrin\u2010conjugated anticanine <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34 antibody was used to stain peripheral blood <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cells, and these were enumerated using a flow cytometer. The <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cell counts were compared between groups and tested (in the <jats:styled-content style=\"fixed-case\">NFICAD<\/jats:styled-content> group) for correlation with the severity of clinical signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The numbers of peripheral <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cells in dogs with <jats:styled-content style=\"fixed-case\">NFICAD<\/jats:styled-content> (median 1.7) were statistically higher than in dogs with other nonallergic inflammatory diseases (median 1.0; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and healthy control dogs (median 0.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). In dogs with <jats:styled-content style=\"fixed-case\">NFICAD<\/jats:styled-content>, there was no correlation between <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cell numbers and <jats:styled-content style=\"fixed-case\">CADESI<\/jats:styled-content>\u201003 scores or owner\u2010assessed pruritus (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>The results of this study suggest the possible involvement of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cells in dogs with <jats:styled-content style=\"fixed-case\">NFICAD<\/jats:styled-content>. The role of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cells in the aetiopathogenesis of canine atopic dermatitis remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12191","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T05:27:33Z","timestamp":1419398853000},"page":"160","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased numbers of peripheral blood <scp>CD<\/scp>34+ cells in dogs with canine atopic dermatitis"],"prefix":"10.1111","volume":"26","author":[{"given":"Vincent","family":"Bruet","sequence":"first","affiliation":[{"name":"Unit\u00e9 Dermatologie, Parasitologie, Mycologie LUNAM, ONIRIS \u2013 Nantes\u2010Atlantic National College of Veterinary Medicine, Food Science and Engineering NANTES Loire Atlantique France"},{"name":"Unit\u00e9 de Pharmacologie Fonctionnelle et de Pathophysiologie Animale LUNAM, ONIRIS \u2013 Nantes\u2010Atlantic National College of Veterinary Medicine, Food Science and Engineering NANTES Loire Atlantique France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blandine","family":"Lieubeau","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immuno\u2010Endocrinologie Cellulaire et Mol\u00e9culaire LUNAM, ONIRIS \u2013 Nantes\u2010Atlantic National College of Veterinary Medicine, Food Science and Engineering NANTES Loire Atlantique France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Herve","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immuno\u2010Endocrinologie Cellulaire et Mol\u00e9culaire LUNAM, ONIRIS \u2013 Nantes\u2010Atlantic National College of Veterinary Medicine, Food Science and Engineering NANTES Loire Atlantique France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Roussel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Dermatologie, 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