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The role of other antibody isotypes and nonenvironmental allergens in disease pathogenesis remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this review is to provide an update on advances in the understanding of the relevance of specific antibody isotypes, autoallergens and nonenvironmental allergens in the pathogenesis of canine<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Citation databases, abstracts and proceedings from international meetings published between 2001 and 2013 were reviewed. Where necessary, older articles were included for background information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neither total nor allergen\u2010specific IgE necessarily correlates with clinical disease in canine<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Some dogs exhibit clinical signs that are indistinguishable from<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>but have no demonstrable allergen\u2010specific IgE (atopic\u2010like dermatitis). Allergen\u2010specific immunoglobulin\u00a0G may be demonstrated in canine<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, but there is no evidence that this isotype plays a role in disease development. Although humans with<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>may develop serum IgE against autoallergens, this finding has not been substantiated in the dog. In contrast, adverse food reactions are frequently co\u2010associated with<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>in the dog. Ingestion of food and environmental allergens may trigger exacerbations of<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Determination of the role of IgE in the pathogenesis of canine<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>still requires clarification. Clinical trials and research studies must distinguish atopic dogs with allergen\u2010specific IgE or\u00a0skin test reactivity from those without. There is no convincing evidence demonstrating a pathogenic role for either allergen\u2010specific immunoglobulin\u00a0G or autoallergens in canine<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, but food items may be triggers for disease flares in certain individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12201","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T11:27:29Z","timestamp":1424950049000},"page":"115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis"],"prefix":"10.1111","volume":"26","author":[{"given":"Cherie M.","family":"Pucheu\u2010Haston","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences School of Veterinary Medicine Louisiana State University 1909 Skip Bertman Drive Baton Rouge LA 70803 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Bizikova","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa N. 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