{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:21:20Z","timestamp":1789928480978,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Bacteria of the <jats:italic>Burkholderia cepacia<\/jats:italic> complex (Bcc) are ubiquitous Gram\u2010negative bacilli associated with fatal nosocomial infections in humans; multi\u2010antibiotic resistance makes this organism a serious threat in hospital settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the historical, clinicopathological and treatment characteristics of Bcc\u2010associated deep skin infections in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Six dogs with skin infections in which skin bacterial cultures resulted in pure growth of Bcc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study with review of medical records and skin biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All dogs were receiving oral ciclosporin at the time of skin infection development. All dogs were castrated males and four of six were West Highland white terriers. Cutaneous lesions consistent with deep pyoderma were confined mainly to the trunk. In all dogs skin cytology revealed a strong inflammatory response, with moderate to abundant numbers of intracellular (neutrophils and macrophages) and extracellular bacilli. In three dogs histopathology showed a multifocal, nodular to coalescing pyogranulomatous dermatitis associated with multifocal folliculitis and furunculosis. Tissue Giemsa and Gram stains identified numerous Gram\u2010negative rods within macrophages. Antimicrobial susceptibility testing revealed multidrug\u2010resistant Bcc strains with sensitivity to trimethoprim\/sulfonamides in all dogs and to marbofloxacin, piperacillin and ceftazidime in three dogs. Successful treatment was achieved in all dogs using trimethoprim\/sulfonamides or quinolones (marbofloxacin, ciprofloxacin) or doxycycline in conjunction with ciclosporin withdrawal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Clinicians should be aware of the rare potential for Bcc\u2010associated deep skin infections in dogs receiving oral ciclosporin. Owners should be made conscious of the potential transmission risk to humans or other animals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12210","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T06:58:58Z","timestamp":1431413938000},"page":"287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Deep pyoderma caused by <i><scp>B<\/scp>urkholderia cepacia<\/i> complex associated with ciclosporin administration in dogs: a case series"],"prefix":"10.1111","volume":"26","author":[{"given":"Frane","family":"Banovic","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences North Carolina State University College of Veterinary Medicine 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine University of Minnesota 1352 Boyd Ave, C339 VMC, St Paul MN 55108 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Robson","sequence":"additional","affiliation":[{"name":"Animal Skin and Allergy Service Melbourne Veterinary Specialist Centre 70 Blackburn Road Glen Waverley VIC 3150 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology North Carolina State University College of Veterinary Medicine 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Olivry","sequence":"additional","affiliation":[{"name":"Department of 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