{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:34:46Z","timestamp":1787830486833,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of dogs with chronic juxtamucosal erosive lesions and histopathology typical of cutaneous lupus erythematosus (<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>We report herein 21 dogs with mucocutaneous erosive lesions and lupus\u2010specific histopathology that we propose to be affected with mucocutaneous lupus erythematosus (<jats:styled-content style=\"fixed-case\">MCLE<\/jats:styled-content>), another variant of chronic<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion criteria were the presence of the following: (i)\u00a0a &gt;2\u00a0month history of chronic or recurrent skin lesions; (ii)\u00a0erosions or ulcers predominating at mucosae or mucocutaneous junctions; (iii)\u00a0microscopic lesions of<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>(i.e. a lymphocyte\u2010rich interface dermatitis with basal keratinocyte damage); and (iv)\u00a0a lack of complete remission following antimicrobials. Clinical questionnaires and skin biopsies were reviewed. Direct immunofluorescence and antinuclear antibody serology were performed whenever possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More than half of the 21 dogs were German shepherds or their crosses. The disease affected mostly dogs in their mid\u2010adulthood and there was an over\u2010representation of females. Erosions and ulcers predominated at genital\/perigenital and anal\/perianal areas, with a lower frequency of involvement of periocular, perioral and perinasal regions. In these dogs, there were no clinical signs suggestive of an associated systemic lupus erythematosus. Microscopic lesions were specific for<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>, but they were patchy and often infected with bacteria. The most common immunological finding was focal IgG deposition at the basement membrane zone. Lesions responded to varying interventions, but oral glucocorticoids led to a shorter time to complete remission. Relapses were common upon treatment tapering.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>These observations support<jats:styled-content style=\"fixed-case\">MCLE<\/jats:styled-content>being another variant of canine<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12217","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T23:38:35Z","timestamp":1434757115000},"page":"256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mucocutaneous lupus erythematosus in dogs (21 cases)"],"prefix":"10.1111","volume":"26","author":[{"given":"Thierry","family":"Olivry","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research North Carolina State University Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Rossi","sequence":"additional","affiliation":[{"name":"VRCC Veterinary Specialty &amp; Emergency Hospital 3550 South Jason Street Englewood CO 80110 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frane","family":"Banovic","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"},{"name":"Center for Comparative Medicine and Translational Research North Carolina State University Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith E.","family":"Linder","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine and Translational Research North Carolina State University Raleigh NC 27606 USA"},{"name":"Department of Population Health and Pathobiology College of Veterinary Medicine North Carolina State University 1060 William Moore Drive Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600203"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/ddg.12254","article-title":"Lupus erythematosus. Part\u00a0II: clinical picture, diagnosis and treatment","volume":"12","author":"Ziemer M","year":"2014","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb08215.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00569.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/11310780-000000000-00000"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(79)90009-6"},{"key":"e_1_2_6_9_1","first-page":"205","article-title":"Discoid lupus erythematosus in the dog: 22 cases [in French]","volume":"22","author":"Olivry T","year":"1987","journal-title":"Prat Med Chir Anim Comp"},{"key":"e_1_2_6_10_1","first-page":"539","article-title":"Immune\u2010mediated dermatoses in domestic animals: ten years after \u2013 part\u00a0II","volume":"9","author":"Scott DW","year":"1987","journal-title":"Comp Cont Educ Pract Vet"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00468.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2001.00212.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00393.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00994.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12139"},{"key":"e_1_2_6_16_1","first-page":"493","article-title":"Discoid lupus erythematosus","volume":"36","author":"Poirier N","year":"1995","journal-title":"Can Vet J"},{"key":"e_1_2_6_17_1","first-page":"323","article-title":"Recto No.38 (perivulvar discoid lupus erythematosus)","volume":"32","author":"Bensignor E","year":"1997","journal-title":"Prat Med Chir Anim Comp"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.154.24.752"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-5-761"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2736\/jjvd.20.9"},{"key":"e_1_2_6_21_1","first-page":"427","article-title":"The utility of the lupus band test on sun\u2010protected non\u2010lesional skin for the diagnosis of systemic lupus erythematosus","volume":"17","author":"Cardinali C","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.01.007"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(88)90032-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2460\/ajvr.1988.49.01.46","article-title":"Systemic lupus erythematosus in a colony of dogs","volume":"49","author":"Monier JC","year":"1988","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90101-U"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.08.019"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00652.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812463406"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2004.tb11165.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00396.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2001.0510"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12142"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T19:24:38Z","timestamp":1748460278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/vde.12217"],"URL":"https:\/\/doi.org\/10.1111\/vde.12217","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]},"assertion":[{"value":"2015-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}