{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:45:33Z","timestamp":1771667133960,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T00:00:00Z","timestamp":1435017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is presumed to be an autoimmune disorder in the dog; primary adrenal insufficiency (Addison's disease) is associated with immune\u2010mediated destruction of the adrenal cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>In this case report we describe a dog with primary hypoadrenocorticism that developed generalized vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 4\u2010year\u2010old spayed female cross\u2010bred dog developed signs of Addison's disease and this was confirmed by biochemical testing; the dog was treated with fludrocortisone acetate and then desoxycorticosterone pivalate. Three months after the diagnosis, the dog developed depigmentation of the whole hair coat and of several focal areas of the skin. Histopathological findings were consistent with vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>Dogs with immune\u2010mediated disease may develop other manifestations of immune\u2010mediated disease, including a combination of Addison's disease and vitiligo. The cause in this case was not determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12228","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T05:25:21Z","timestamp":1435123521000},"page":"376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Generalized vitiligo in a dog with primary hypoadrenocorticism"],"prefix":"10.1111","volume":"26","author":[{"given":"Eleonora","family":"Malerba","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna Via Tolara di Sopra 50 Ozzano dell'Emilia 40064 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Morini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna Via Tolara di Sopra 50 Ozzano dell'Emilia 40064 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Fracassi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna Via Tolara di Sopra 50 Ozzano dell'Emilia 40064 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,23]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"e_1_2_2_3_1","first-page":"200","volume-title":"Skin Diseases of the Dog and Cat","author":"Gross TL"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-181-42275"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1368"},{"key":"e_1_2_2_6_1","first-page":"789","article-title":"Autoimmunity and Addison's disease in the dog","volume":"22","author":"Schaer M","year":"1986","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_2_7_1","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1001\/jama.1992.03490200151017","article-title":"Immunologic aspects of endocrine diseases","volume":"268","author":"Baker JR","year":"1992","journal-title":"JAMA"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000182585"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1995.0009"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2011.11.015"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12228","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:07:16Z","timestamp":1696151236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,23]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/vde.12228"],"URL":"https:\/\/doi.org\/10.1111\/vde.12228","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,23]]},"assertion":[{"value":"2015-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}