{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:16:37Z","timestamp":1768342597741,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata is a T\u2010cell mediated autoimmune disease that occurs in humans and various other mammalian species. When the disease progresses to total alopecia it is defined as alopecia areata universalis (AAU), although this outcome has only been described in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/objectives<\/jats:title><jats:p>To describe a case of canine alopecia areata universalis and its clinical outcome after 22\u00a0months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<\/jats:title><jats:p>A 9\u2010year\u2010old intact male cross\u2010breed hunting dog was presented with generalized and complete noninflammatory alopecia of 12\u201314\u00a0months duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical examination; histopathological and immunohistochemical examination of skin biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was loss of all body hair including eyelashes and vibrissae. The histopathological and immunohistochemical findings supported a diagnosis of long\u2010standing alopecia areata. Treatment with oral ciclosporin was associated with hair regrowth but muzzle hair, most eyelashes and whiskers were still lacking after 17\u00a0months of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>To the best of the author's knowledge this is the first documented case of canine AAU. The clinical and histopathological features were consistent with a diagnosis of AAU as defined in humans. Treatment with oral ciclosporin resulted in near complete resolution of the alopecia, but after 5\u00a0months without treatment the alopecia did not relapse and spontaneous resolution cannot be ruled out.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12232","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T11:15:27Z","timestamp":1435662927000},"page":"379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Alopecia areata universalis in a dog"],"prefix":"10.1111","volume":"26","author":[{"given":"Pedro J.","family":"Ginel","sequence":"first","affiliation":[{"name":"Department of Animal Medicine and Surgery University of C\u00f3rdoba Campus de Rabanales 14014 C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery University of C\u00f3rdoba Campus de Rabanales 14014 C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"P\u00e9rez\u2010Aranda","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery University of C\u00f3rdoba Campus de Rabanales 14014 C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Zafra","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Comparative Pathology University of C\u00f3rdoba Campus de Rabanales 14014 C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mozos","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Comparative Pathology University of C\u00f3rdoba Campus de Rabanales 14014 C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05610.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2007.00212.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12013"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31942"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1103442"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1994.tb00024.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00392.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752487.ch18"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1996.tb00229.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-7618-0.50013-4"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00489.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.1.12"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12232","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:07:19Z","timestamp":1696151239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/vde.12232"],"URL":"https:\/\/doi.org\/10.1111\/vde.12232","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]},"assertion":[{"value":"2015-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}