{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:04:47Z","timestamp":1791950687443,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"ICF Cremona, Italy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a lack of studies comparing topical antiseptics to systemic antibiotics in the treatment of canine superficial pyoderma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To compare the efficacy of topical chlorhexidine with systemic amoxicillin\u2013clavulanic acid for the treatment of canine superficial pyoderma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>\n                      A randomized controlled trial was conducted in dogs with superficial pyoderma. Group T (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031) was treated topically with 4% chlorhexidine digluconate shampoo (twice weekly) and solution (once daily) for 4\u00a0weeks. Group S (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) was treated orally with amoxicillin\u2013clavulanic acid (25\u00a0mg\/kg) twice daily for 4\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bacterial culture and susceptibility testing were performed on clinical specimens collected before treatment. Severity of lesions and number of intracellular bacteria were evaluated using four\u2010point scales to calculate a total pyoderma score for each dog. Pruritus was assessed by owners using a visual analog scale (range 0\u201310). Scores were analysed for statistical differences between groups T and S.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\n                      was isolated from 48 dogs, including eight meticillin\u2010resistant strains (MRSP). Although the number of dogs was small, no significant differences in pyoderma and pruritus scores were observed between groups throughout the study except for day 1, when group S had a significantly higher total score than group T (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.03). Treatment with chlorhexidine products resulted in resolution of clinical signs in all dogs including those infected with MRSP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and clinical importance<\/jats:title>\n                    <jats:p>Topical therapy with chlorhexidine digluconate products may be as effective as systemic therapy with amoxicillin\u2013clavulanic acid. This finding supports the current recommendations to use topical antiseptics alone for the management of superficial pyoderma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.12233","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T13:59:51Z","timestamp":1435931991000},"page":"339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Effectiveness of a combined (4% chlorhexidine digluconate shampoo and solution) protocol in MRS and non\u2010MRS canine superficial pyoderma: a randomized, blinded, antibiotic\u2010controlled study"],"prefix":"10.1111","volume":"26","author":[{"given":"Stefano","family":"Borio","sequence":"first","affiliation":[{"name":"Servizi Dermatologici Veterinari 12 via Italia I\u201010099 San Mauro Torinese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Colombo","sequence":"additional","affiliation":[{"name":"Servizi Dermatologici Veterinari 24 via Felice Musazzi I\u201020025 Legnano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Veterinary Science University of Torino 44 via Leonardo Da Vinci I\u201010095 Grugliasco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"De Lucia","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Privata San Marco 114\u2044C via Sorio I\u201035141 Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Damborg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Health and Medical Sciences University of Copenhagen Gr\u00f8nneg\u00e5rdsvej 15 DK\u20101870 Frederiksberg C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Guardabassi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Health and Medical Sciences University of Copenhagen Gr\u00f8nneg\u00e5rdsvej 15 DK\u20101870 Frederiksberg C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"108","volume-title":"Muller & Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101069"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12118"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00635.x"},{"issue":"1","key":"e_1_2_6_6_1","first-page":"37","article-title":"Multidrug and methicillin resistance in Staphylococcus spp. canine recurrent superficial and deep pyoderma in Italy","volume":"19","author":"Vercelli A","year":"2008","journal-title":"Vet Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2010.09.014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01165.x"},{"key":"e_1_2_6_9_1","first-page":"11","article-title":"Uso prudente e razionale degli antibiotic nel trattamento delle piodermiti nel cane e nel gatto (Cautious and rational use of antibiotics in the treatment of canine and feline pyoderma)","volume":"23","author":"Guardabassi L","year":"2009","journal-title":"Veterinaria"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.01002.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2736\/jjvd.12.1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00898.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.c4899"},{"key":"e_1_2_6_14_1","volume-title":"Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals; 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