{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:43:38Z","timestamp":1773776618865,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia X (hair cycle arrest) is a relatively frequent hair growth disorder in Pomeranians and several other breeds, characterized by symmetrical, noninflammatory alopecia without systemic signs. The cause and pathogenesis remain unknown. Previously reported treatments with various topical and systemic drugs have been variably successful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that superficial mechanical skin trauma applied with a microneedling device would induce long\u2010term hair regrowth at treated sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Two neutered female Pomeranian siblings with histologically confirmed alopecia X. Previous treatments with deslorelin, melatonin and topical minoxidil had failed to produce significant hair regrowth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The dogs were anaesthetized and the skin was punctured with a microneedling device. Dogs were followed over a period of 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five weeks\u00a0after microneedling hair regrowth started, followed by a reduction in hyperpigmentation of affected skin. After 12\u00a0weeks there was a 90% improvement in coat coverage at previously alopecic areas. Twelve months after the procedure, coat conditions remained stable. No adverse effects were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>This is the first report of microneedling to induce hair regrowth in dogs affected by alopecia X. Long\u2010term studies with microneedling in a larger number of dogs with alopecia X will need to be performed to confirm these preliminary results and to further evaluate if hair\u2010regrowth is permanent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12236","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T23:20:01Z","timestamp":1436916001000},"page":"387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Microneedling as a successful treatment for alopecia X in two <scp>P<\/scp>omeranian siblings"],"prefix":"10.1111","volume":"26","author":[{"given":"Steve","family":"Stoll","sequence":"first","affiliation":[{"name":"Stolldesign Wilstrasse 6 6436 Muotathal Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Dietlin","sequence":"additional","affiliation":[{"name":"Hautarzt Zentrum Oristalstrasse 20 4410 Liestal Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia S.","family":"Nett\u2010Mettler","sequence":"additional","affiliation":[{"name":"Dermatologie und Allergologie f\u00fcr Tiere c\/o Ennetseeklinik f\u00fcr Kleintiere AG Rothusstrasse 2 6331 Hueneberg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"531","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00372.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00403.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.1494"},{"key":"e_1_2_6_6_1","first-page":"1317","article-title":"Identifying and treating sex\u2010hormone dermatoses in dogs","volume":"14","author":"Chalmers SA","year":"1990","journal-title":"Vet Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12073"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12148"},{"key":"e_1_2_6_9_1","first-page":"148","volume-title":"Hair Loss Disorders in Domestic Animals","author":"Frank L","year":"2009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.11.014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.03.038"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2013.12.008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/maj.2002.126195"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.53096"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12095"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.129989"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2012.11.001"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12236","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:07:21Z","timestamp":1696151241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/vde.12236"],"URL":"https:\/\/doi.org\/10.1111\/vde.12236","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]},"assertion":[{"value":"2015-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}