{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:56:29Z","timestamp":1761663389289},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dermatology Chapter of the Australia and New Zealand College of Veterinary Scientists","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is a general belief that immune system cells are present in larger numbers in the planum nasale and adjacent haired skin than in other locations in the dog. However, little published information about the normal histological appearance of the skin of this area exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The aim was to obtain information about the normal histological appearance of canine skin for specific anatomical regions of the planum nasale and the haired skin adjacent to the planum nasale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Samples from three sites were obtained from the planum nasale and adjacent haired skin of 25 dogs of varying age, breed and sex, with no evidence of dermatological or respiratory disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples were analysed to determine and quantify the immune system cells present in the samples. Slides were stained with haematoxylin and eosin or toluidine blue; immunohistochemical stains for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>79a were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immune system cells, including lymphocytes and plasma cells, were either very rare or present in low numbers. The majority of lymphocytes were of T\u2010cell origin, with only infrequent B\u00a0cells identified. Samples contained numerous melanophages, consistent with pigmentary incontinence, regardless of the presence or absence of inflammatory cells. Mast cells and plasma cells were present in low numbers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inflammatory change noted in diagnostic biopsies from this area from dogs with clinical disease is likely to be of pathological significance. However, pigmentary incontinence appears to be common at this site in clinically normal dogs without significant inflammatory cell infiltration and is therefore not necessarily of pathological significance when seen in isolation in this location.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.12238","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T08:19:07Z","timestamp":1437380347000},"page":"359","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A preliminary survey of the histopathological features of skin from the planum nasale and adjacent skin of dogs unaffected by dermatological or respiratory disease"],"prefix":"10.1111","volume":"26","author":[{"given":"John H. C.","family":"Hutt","sequence":"first","affiliation":[{"name":"Dermatology for Animals 263 Appleby Road Stafford Heights QLD 4053 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Focus EyePathLab 24 Joelle Lane Mount Glorious QLD 4520 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim J.","family":"Scase","sequence":"additional","affiliation":[{"name":"Bridge Pathology Ltd 637 Gloucester Road Horfield Bristol BS7 0BJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Shipstone","sequence":"additional","affiliation":[{"name":"Dermatology for Animals 263 Appleby Road Stafford Heights QLD 4053 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"301","volume-title":"Textbook of Veterinary Histology","author":"Monteiro\u2010Riviere NA","year":"1993"},{"key":"e_1_2_5_3_1","first-page":"85","volume-title":"Color Atlas of Veterinary Histology","author":"Bacha WJ","year":"2000"},{"key":"e_1_2_5_4_1","first-page":"11","volume-title":"Color Atlas and Text of Surgical Pathology of the Dog and Cat. Dermatopathology and Skin Tumors","author":"Yager JA","year":"1994"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.22233\/9781905319886.4","volume-title":"BSAVA Manual of Canine and Feline Dermatology","author":"Shearer DH","year":"2012"},{"key":"e_1_2_5_6_1","volume-title":"Proceedings of the Annual Meeting of the Australasian College of Veterinary Scientists Dermatology Chapter","author":"Bettenay SV","year":"2003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-1050-2_3","volume-title":"Histopathology Methods and Protocols","author":"Feldman AT","year":"2014"},{"key":"e_1_2_5_8_1","first-page":"15","volume-title":"Color Atlas and Text of Surgical Pathology of the Dog and Cat. Dermatopathology and Skin Tumors","author":"Yager JA","year":"1994"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvde.12238","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.12238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:07:06Z","timestamp":1696151226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.12238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,20]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/vde.12238"],"URL":"https:\/\/doi.org\/10.1111\/vde.12238","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,20]]},"assertion":[{"value":"2015-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}